J Korean Neurol Assoc.
2012 May;30(2):128-131.
An Autopsy Case of Amyotrophic Lateral Sclerosis with Neuroinflammatory change
- Affiliations
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- 1Department of Neurology, Hanyang University College of Medicine, Seoul, Korea. kimsh1@hanyang.ac.kr
- 2Department of Anatomy and Cell Biology, Hanyang University College of Medicine, Seoul, Korea.
Abstract
- Neuroinflammation such as reactive gliosis and microglial activations are important pathological findings of ALS. We present a first autopsy case of ALS in Korea related with neuroinflammatory change. A 67-year-old ALS patient suddenly expired due to accidental head trauma. Gross autopsy finding showed marked atrophic change in spinal cord. Pathological finding include a marked loss of motor neurons, reactive gliosis and microglial infiltrations. These findings suggest neuroinflammation may play a role in pathogenesis of ALS.
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