Nucl Med Mol Imaging.  2022 Apr;56(2):102-104. 10.1007/s13139-021-00732-4.

[68 Ga]Ga-PSMA-11 Small Bowel Uptake in Crohn’s Disease: Revisiting the “Non-specificity” of PSMA Ligands

• Singh H
• Chandekar KR
• Tanigassalam S
• Kavanal AJ
• Bhattacharya A
• Mavuduru RS

• KMID: 2528454
• DOI: http://doi.org/10.1007/s13139-021-00732-4

Abstract

The rapidly evolving clinical utility of prostate-specific membrane antigen (PSMA) PET/CT as an imaging modality for prostate cancer (PCa) has brought to the forefront a multitude of non-prostatic diseases also exhibiting PSMA radioligand uptake. We report a case of a 71-year-old male with PCa who underwent PSMA PET/CT for recurrence evaluation. The scan demonstrated [68 Ga]Ga-PSMA-11 uptake in the distal ileum. Retrospective enquiry revealed that the patient was a known case of Crohn’s disease. This case highlights an uncommon finding of PSMA radioligand uptake in the distal small bowel (non-prostatic benign pathological uptake) in a patient with known Crohn’s disease, which may be misinterpreted in the evaluation of PCa.

Keyword

Prostate-specific membrane antigen (PSMA); Prostate cancer; PET/CT; Inflammatory bowel disease (IBD) ; Crohn’s disease