Nucl Med Mol Imaging.  2023 Dec;57(6):298-300. 10.1007/s13139-023-00805-6.

⁶⁸Ga‑PSMA‑11 PET/CT in Bilateral Clear Cell Renal Cell Carcinoma: an Intra‑patient Comparison Between High and Low Grade Tumors

• Urso L
• Rocca G
• Conti G
• Colella A
• Nieri A
• Cittanti C
• Ippolito C
• Bartolomei M

• KMID: 2549942
• DOI: http://doi.org/10.1007/s13139-023-00805-6

Abstract

Recent studies have outlined the emerging role of ⁶⁸Ga-PSMA-11 PET/CT in the diagnostic algorithm of clear cell renal cell carcinoma (ccRCC). We report a unique intra-patient comparison of bilateral primary ccRCC imaged with ⁶⁸Ga-PSMA-11 PET/CT. Although both tumors resulted ⁶⁸Ga-PSMA-11 avid, we found a remarkable discrepancy in uptake intensity between the high grade and the low grade ccRCC. This case confirms previous evidence reporting that SUVmax on ⁶⁸Ga-PSMA-11 PET/CT could be used to discriminate aggressive high grade from more indolent low grade ccRCC, due to their different endothelial expression of PSMA.

Keyword

⁶⁸Ga-PSMA PET/CT; PSMA PET; ccRCC; Renal cell carcinoma; Clear cell renal cell carcinoma