Nucl Med Mol Imaging.
2023 Dec;57(6):298-300. 10.1007/s13139-023-00805-6.
68Ga‑PSMA‑11 PET/CT in Bilateral Clear Cell Renal Cell Carcinoma: an Intra‑patient Comparison Between High and Low Grade Tumors
- Affiliations
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- 1Nuclear Medicine Unit, Oncological Medical and Specialists Department, University Hospital of Ferrara, Ferrara, Italy
- 2Urology Unit, Surgical Department, University Hospital of Ferrara, Ferrara, Italy
- KMID: 2549942
- DOI: http://doi.org/10.1007/s13139-023-00805-6
Abstract
- Recent studies have outlined the emerging role of 68Ga-PSMA-11 PET/CT in the diagnostic algorithm of clear cell renal cell carcinoma (ccRCC). We report a unique intra-patient comparison of bilateral primary ccRCC imaged with 68Ga-PSMA-11 PET/CT. Although both tumors resulted 68Ga-PSMA-11 avid, we found a remarkable discrepancy in uptake intensity between the high grade and the low grade ccRCC. This case confirms previous evidence reporting that SUVmax on 68Ga-PSMA-11 PET/CT could be used to discriminate aggressive high grade from more indolent low grade ccRCC, due to their different endothelial expression of PSMA.
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