Nucl Med Mol Imaging.  2024 Jun;58(3):150-151. 10.1007/s13139-024-00839-4.

Discordant Molecular Imaging Findings with 2‑[18F]FDG and ­[68Ga] Ga‑PSMA PET/CT in a Patient with Both Bladder and Prostate Cancer

Affiliations
  • 1Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India

Abstract

The prevalence of double primary prostate and bladder cancer is not uncommon. Though both share a common pathway of malignant transformation, they bear to differ in the case of 2-[18F]FDG PET/CT and ­[68Ga]Ga-PSMA uptake. We present a case of double primary cancer involving the bladder and prostate, where the prostatic primary showed intense [68Ga]GaPSMA uptake with non-avid skeletal and pulmonary metastases, which showed intense 2-[18F]FDG uptake, thus showing discordance due to different clonal origins.

Keyword

2-[18F]FDG PET/CT; [68Ga]Ga-PSMA PET/CT; Urinary bladder cancer; Prostate cancer; Tumor biology; [99mTc]Tc-MDP bone scan
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