Nucl Med Mol Imaging.  2021 Aug;55(4):199-202. 10.1007/s13139-021-00701-x.

Mismatched Imaging Findings of Prostate Cancer Diagnosis: 68 Ga-PSMA PET/CT vs mpMRI

• Lopci E
• Colombo P
• Lazzeri M

• KMID: 2519274
• DOI: http://doi.org/10.1007/s13139-021-00701-x

Abstract

Multiparametric magnetic resonance imaging (mpMRI) is the modality of choice for initial diagnosis of prostate cancer (PCa), including biopsy-naïve patients. Nevertheless, clinicians must be aware of the possibility that up to one-fourth of clinically significant cancers might be missed by the modality. Acknowledgment of this occurrence and the increased availability of 68 Ga-PSMA PET/CT in clinical routine, open the door to new, fascinating, indications for this functional modality in the context of PCa detection. With the case herein illustrated, we report a paradigmatic example of mismatch findings between PET/CT and mpMRI better elucidating the potential indication.

Keyword

68 Ga-PSMA PET/CT; MpMRI; Prostate cancer; Fusion biopsy; Primary diagnosis