Kosin Med J.  2021 Dec;36(2):69-78. 10.7180/kmj.2021.36.2.69.

The Roles of Human Endogenous Retroviruses (HERVs) in Inflammation

• Ko EJ
• Cha HJ

• KMID: 2524669
• DOI: http://doi.org/10.7180/kmj.2021.36.2.69

Abstract

Human endogenous retroviruses (HERVs) are ancient, currently inactive, and non-infectious due to recombination, deletions, and mutations in the host genome. However, HERV-derived elements are involved in physiological phenomena including inflammatory response. In recent studies, HERV-derived elements were involved directly in various inflammatory diseases including autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Sjogren’s syndrome. Regarding the involvement of HERV-derived elements in inflammation, two possible mechanisms have been proposed. First, HERV-derived elements cause nonspecific innate immune processes. Second, HERV-derived RNA or proteins might stimulate selective signaling mechanisms. However, it is unknown how silent HERV elements are activated in the inflammatory response and what factors and signaling mechanisms are involved with HERV-derived elements. In this review, we introduce HERV-related autoimmune diseases and propose the possible action mechanisms of HERV-derived elements in the inflammatory response at the molecular level.

Keyword

Autoimmune disease; Human endogenous retrovirus (HERV); Inflammatory response; Mechanism

Figure

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  Fig. 1 Autoimmune diseases associated with HERV-derived elements

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  Fig. 2 Schematic diagram of the HERV mediated immune response pathway

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