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A Study of the Standardization and the External Quality Assessment for Antinuclear Antibody, Anti-Double-Stranded DNA, and AntiExtractable Nuclear Antigen Antibody Testing

Lee J, Kim DS, Park J

Autoantibodies to nuclear antigens (antinuclear antibodies, ANAs), doublestranded DNA (dsDNA), and extractable nuclear antigens (ENAs) are useful for the early diagnosis and appropriate treatment of autoimmune diseases. This study aimed...
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Associated Comorbidities of Patients with Multiple Dermatofibromas: A Single-Center Retrospective Study and a Review of the Literature

Yook HJ, Kim YH, Han JH, Bang CH, Lee JH, Park YM, Lee JY

  • KMID: 2525569
  • Korean J Dermatol.
  • 2022 Jan;60(1):25-34.
Background: Dermatofibromas (DF) are fibrohistiocytic tumors of unknown etiology, and multiple DF (MDF) are relatively rare. MDF have been reported in the setting of autoimmune diseases, human immunodeficiency virus infection,...
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The Roles of Human Endogenous Retroviruses (HERVs) in Inflammation

Ko EJ, Cha HJ

Human endogenous retroviruses (HERVs) are ancient, currently inactive, and non-infectious due to recombination, deletions, and mutations in the host genome. However, HERV-derived elements are involved in physiological phenomena including inflammatory...
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Sensorineural Hearing Loss of Suspected Autoimmune Etiology: Two Cases of Cogan’s Syndrome

Ahn J, Kim B, Cho KR, Chang YS

Cogan’s syndrome is a rare inflammatory disease characterized by non-syphilitic keratitis and vestibulo-auditory symptoms including hearing loss, tinnitus, and vertigo. Although its precise pathogenesis is not known, Cogan’s syndrome is...
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Thyroid and Gut Microbiome

Kwon SK, Kim N, Park YJ

The gut microbiome affects the enterohepatic recycling of thyroid hormone and the metabolism and absorption of micronutrients including iodine and selenium. Changes in thyroid function trigger changes in the neuro-muscular...
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The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus

Pellenz FM, Dieter C, Duarte GCK, Canani LH, de Souza BM, Crispim D

Background: Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and pro-inflammatory pathways in pancreatic β-cells...
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Safety of Tacrolimus in Autoimmune Disease: Results From Post-marketing Surveillance in South Korea

Yoo WH, Lee SI, Kim TH, Sung JJ, Kim SM, Hua F, Sumarsono B, Park SH

Objective: Tacrolimus, a macrolide immunosuppressant, is approved in Korea for the treatment of rheumatoid arthritis (RA), lupus nephritis (LN) and myasthenia gravis (MG). We report three prospective post-marketing surveillance studies...
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Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies

Jeong JH, Lee SY, Han HS, Kim JH, Sung IK, Park HS

Autoimmune gastritis is a corpus-dominant type of gastritis with positive serum anti-parietal cell antibodies (APCA) and/or anti-intrinsic factor antibodies. Serum APCA and pepsinogen (PG) assays were performed in subjects with...
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T-cell Large Granular Lymphocytic Leukemia Presenting as Post-transplant Lymphoproliferative Disorder: A Report of Two Cases and Literature Review

Kim S, Cho YU, Jang S, Seo EJ, Park CJ

T-cell large granular lymphocytic leukemia (T-LGLL) can present as a form of post-transplant lymphoproliferative disorder. Here, we described clinicopathological findings from 58 cases of post-transplant T-LGLL (our own 2 cases...
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Varicella zoster virus (VZV)-specific immunity and subclinical VZV reactivation in patients with autoimmune diseases

Lee KH, Choi S, Kwon JS, Kim SH, Park SY

Background/Aims: The risk of herpes zoster (HZ) is increased in patients with autoimmune diseases (AID), probably due to immunosuppressive therapy. Methods: This prospective cross-sectional study investigated varicella zoster virus (VZV)-specific immunity...
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Development and Stability Evaluation of In- House Prepared External Quality Controls for Autoimmune Disease Tests

Shin S, Park J

Background: The control samples for external quality assessment (EQA) must be highly stable during the EQA process. This study aimed to evaluate the stability of in-house prepared external quality controls...
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Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists

Min HK, Kim SH, Lee SH, Kim HR

Interstitial pneumonia with autoimmune feature (IPAF) is a recently established disease entity that is comprised of interstitial lung diseases with evidence of autoimmune features but that does not fulfill the...
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Current advances in the treatment of autoimmune-associated interstitial lung diseases

Lee S, Lee JH

Autoimmune-associated interstitial lung disease (ILD) is a widespread and clinically significant form of autoimmune diseases. ILD can be present in most type of autoimmune diseases. Scleroderma, Sjogren syndrome, rheumatoid arthritis,...
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Successful management of systemic lupus erythematosus with levamisole in a Dachshund dog

Kim DH, Han HJ, Kim JH

A 5-year-old neutered female Dachshund dog presented with a 3-month history of hyperthermia, skin lesions, and shifting lameness. Based on physical examination, blood tests, urinalysis, and radiographs, the dog was...
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Biologic therapies for the treatment of systemic lupus erythematosus

Park SH

Systemic lupus erythematosus is a typical autoimmune disease with a complex etiology, including the interaction of genetic/epigenetic factors and environmental and hormonal factors with innate immune cells or B/T lymphocytes....
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Induction of anti-aquaporin 5 autoantibodies by molecular mimicry in mice

Lee A, Choi Y

Molecular mimicry is the most common mechanism that breaches self-tolerance. We previously identified autoantibodies to aquaporin-5 (AQP5) in the sera of patients with Sjögren’s syndrome and found that the aquaporin...
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Immunotherapy of Autoimmune Diseases with Nonantibiotic Properties of Tetracyclines

Park CS, Kim SH, Lee CK

Tetracyclines, which have long been used as broad-spectrum antibiotics, also exhibit a variety of nonantibiotic activities including anti-inflammatory and immunomodulatory properties. Tetracyclines bind to the 30S ribosome of the bacteria and...
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Pathogenesis of vitiligo

Seok SH, Kim DH

Vitiligo is an autoimmune disease in which CD8+ T-cells target and destroy melanocytes, leaving areas of skin without pigment production. Nonsegmental vitiligo, the classical form of the disease, results in...
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Crosstalk between the Producers and Immune Targets of IL-9

Do-Thi VA, Lee JO, Lee H, Kim YS

IL-9 has been reported to play dual roles in the pathogenesis of autoimmune disorders and cancers. The collaboration of IL-9 with microenvironmental factors including the broader cytokine milieu and other...
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Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus

Li Y, Zhou Y, Zhao M, Zou J, Zhu Y, Yuan X, Liu Q, Cai H, Chu CQ, Liu Y

Background No currently available biomarkers or treatment regimens fully meet therapeutic needs of type 1 diabetes mellitus (T1DM). Circular RNA (circRNA) is a recently identified class of stable noncoding RNA that...
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