Gut Liver.  2021 Jul;15(4):537-545. 10.5009/gnl20079.

A Nationwide Cohort Study Shows a Sex-Dependent Change in the Trend of Peptic Ulcer Bleeding Incidence in Korea between 2006 and 2015

  • 1Wonkwang Digestive Disease Research Institute, Wonkwang University, Iksan, Korea
  • 2Good Breath Clinic, Gunpo, Korea
  • 3Scientific Committee, Korean College of Helicobacter and Upper Gastrointestinal Research, Korea
  • 4Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
  • 5Department of Gastroenterology, Wonkwang University Sanbon Hospital, Gunpo, Korea
  • 6National Health Insurance Service, Wonju, Korea
  • 7Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea


The incidence of peptic ulcer disease has decreased in past decades; however, the trends in peptic ulcer bleeding (PUB) are inconsistent among regions. This study aimed to investigate the trends in PUB incidence and the effect of risk factors on PUB in Korea.
The records of patients hospitalized with PUB from 2006 to 2015 were retrieved from the Korean National Health Insurance Service Database. Standardized incidences of PUB were calculated, and the clinical characteristics such as age, sex, Helicobacter pylori infection, drug exposure, comorbidities, and mortality were obtained.
In total, 151,507 hospitalizations with PUB were identified. The overall annual hospitalization rate was 34.98 per 100,000 person-years. The incidence of PUB showed no significant change from 2006 to 2008 and decreased from 2008 to 2015, with an annual change of –2.7% (p<0.05); however, this change was only significant in men. The incidence of PUB was higher in men than in women between 40 and 70 years old and higher in women than in men older than 80 years. From 2006 to 2015, the H. pylori infection rate increased significantly in patients with PUB; however, there was no significant change in exposure to nonsteroidal anti-inflammatory drugs or other drugs that increase the risk of PUB.
Over the past decade, the incidence of PUB has decreased in a sex-specific manner. There has been a decreasing trend in the H. pylori infection rate and no change in exposure to drugs that increase the risk of PUB in Korea.


Anti-inflammatory agents; non-steroidal; Helicobacter pylori; Peptic ulcer hemorrhage; Sex; Incidence
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