Korean J Gastroenterol.  1999 Sep;34(3):295-300.

The Effect of Helicobacter pylori Infection on Peptic Ulcer Bleeding

• Jang BK
• Ahn SH
• Hur JW
• Hwang JS
• Kang YW
• Park SK

Abstract

BACKGROUND/AIMS: Helicobacter pylori (H. pylori) infection is deeply involved in pathogenesis of peptic ulcer. However, the role of H. pylori infection on the peptic ulcer bleeding is not established. We investigated the effect of H. pylori infection on ulcer bleeding by comparision of the incidence of H. pylori infection in patients with bleeding ulcer or non bleeding ulcer.
METHODS
We surveyed 101 patients who were diagnosed as bleeding and non bleeding peptic ulcer by gastroscopy from September, 1997 to June, 1998. We obtained biopsy specimen within 5 cm from pylorus by jumbo biopsy forcep and performed CLO test and Cresyl-Violet stain.
RESULTS
The positive rate of H. pylori infection in the patients with bleeding gastric ulcer was 55% (11 of 20), which was significantly lower than that of patients with non bleeding gastric ulcer, 84% (27 of 32)(p<0.05). The positive rate of H. pylori infection in patients with bleeding duodenal ulcer was 69% (11 of 16), which was not significantly lower than that of patients with non bleeding duodenal ulcer, 81% (27 of 33).
CONCLUSIONS
Our results suggested that H. pylori infection did not have any effect on bleeding in patients with peptic ulcer, especially gastric ulcer.

Keyword

Helicobacter pylori; Peptic ulcer; Bleeding

MeSH Terms

Biopsy
Duodenal Ulcer
Gastroscopy
Helicobacter pylori*
Helicobacter*
Hemorrhage*
Humans
Incidence
Peptic Ulcer*
Pylorus
Stomach Ulcer
Surgical Instruments
Ulcer