Korean J Helicobacter Up Gastrointest Res.  2014 Mar;14(1):18-23. 10.7704/kjhugr.2014.14.1.18.

Complications and Management of Peptic Ulcer Disease

Affiliations
  • 1Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea. baikgh@hallym.or.kr

Abstract

Despite the improvement of medical managements of peptic ulcer and decline of Helicobacter pylori infection, complications of peptic ulcer are still prevalent in clinical practice. This is because of the increased use of ulcerogenic medications such as aspirin or non-steroidal anti-inflammatory drug (NSAID) in elderly patients. Peptic ulcer complications include bleeding, perforation, penetration and gastric outlet obstruction. These complications need to be managed by multidisciplinary approaches such as combination of endoscopic treatment, radiologic embolization, or surgical treatments. In addition to using proton pump inhibitors, H. pylori eradication and discontinuing ulcerogenic medications are essential in the prevention of recurrence. Although uncommon, non-H. pylori, non-NSAID ulcers should be suspected as a potential cause in recurrent cases of peptic ulcer complications.

Keyword

Peptic ulcer hemorrhage; Peptic ulcer perforation; Gastric outlet obstruction

MeSH Terms

Aged
Aspirin
Gastric Outlet Obstruction
Helicobacter pylori
Hemorrhage
Humans
Peptic Ulcer Hemorrhage
Peptic Ulcer Perforation
Peptic Ulcer*
Proton Pump Inhibitors
Recurrence
Ulcer
Aspirin
Proton Pump Inhibitors
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