Korean J Gastroenterol.  2016 Jun;67(6):289-299. 10.4166/kjg.2016.67.6.289.

Peptic Ulcer Disease Associated with Helicobacter pylori Infection

Affiliations
  • 1Division of Gastroenterology & Hepatology, Department of Internal Medicine, Dongguk University School of Medicine, Gyeongju, Korea. chhyang@dongguk.ac.kr

Abstract

Although the global prevalence of peptic ulcer disease (PUD) is decreasing, PUD is still one of the most common upper gastrointestinal diseases in the world due to Helicobacter pylori infection and increased use of non-steroidal anti-inflammatory drugs. In Korea, the prevalence of H. pylori infection is also declining, but it is still the major cause of PUD. The outcomes of H. pylori infection are caused by imbalances between bacterial virulence factors, host factors, and environmental influences. In this review, we describe the prevalence trends of H. pylori infection in Korea, the mechanism of H. pylori infection-related PUD, and treatment strategies.

Keyword

Helicobacter pylori; Peptic ulcer; Prevalence; Epidemiology; Therapy

MeSH Terms

Epidemiology
Gastrointestinal Diseases
Helicobacter pylori*
Helicobacter*
Korea
Peptic Ulcer*
Prevalence
Virulence Factors
Virulence Factors

Figure

  • Fig. 1. Trends of seroprevalence of Helicobacter pylori infection in asymptomatic subjects without a history of H. pylori eradication in 1998, 2005, and 2011 (*p<0.05). Seroprevalence by sex (A), by geographic area (B) and by age (C).18


Reference

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