Int J Oral Biol.  2021 Mar;46(1):7-14. 10.11620/IJOB.2021.46.1.7.

Vinpocetine inhibits the proliferation and induces apoptosis in human colon cancer cells

Affiliations
  • 1Department of Oral Physiology, Pusan National University School of Dentistry, Yangsan 50612, Republic of Korea
  • 2Department of Orthodontics, Pusan National University School of Dentistry, Yangsan 50612, Republic of Korea
  • 3Department of Dental Pharmacology, Pusan National University School of Dentistry, Yangsan 50612, Republic of Korea

Abstract

Vinpocetine induces anti-inflammatory effects in various inflammatory diseases via the inhibition of phosphodiesterase type-1-independent nuclear factor-κB signaling pathway and the release of inflammatory cytokines. In this study, we investigated the effect of vinpocetine on the proliferation of colon cancer cells and its underlying molecular mechanisms. Our data showed that vinpocetine inhibits the viability and proliferation of colon cancer cells. Vinpocetine treatment induced cell death in HCT116 cells, which the percentages of sub-G1 phase were significantly increased, and the apoptosis-related genes were regulated after HCT116 cells were treated with vinpocetine. In sum, our findings indicated that vinpocetine could be a therapeutically useful candidate in the treatment of colon cancer.

Keyword

Vinpocetine; Colon cancer cells; Apoptosis; Proliferation
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