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Ameliorative effect of Abeliophyllum distichum Nakai on benign prostatic hyperplasia in vitro and in vivo

Choi YJ, Fan M, Tang Y, Moon S, Lee SH, Lee B, Bae SM, Lee SM, Kim EK

BACKGROUND/OBJECTIVES: Benign prostatic hyperplasia (BPH) is the most common prostate disease and one of the most common chronic diseases caused by aging in men. On the other hand, there has...
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Snail Promotes Cancer Cell Proliferation via Its Interaction with the BIRC3

Rho SB, Byun HJ, Kim BR, Lee CH

Snail is implicated in tumour growth and metastasis and is up-regulated in various human tumours. Although the role of Snails in epithelial-mesenchymal transition, which is particularly important in cancer metastasis,...
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SOX12 Promotes Thyroid Cancer Cell Proliferation and Invasion by Regulating the Expression of POU2F1 and POU3F1

Su Z, Bao W, Yang G, Liu J, Zhao B

Purpose: SOX12 is overexpressed in many cancers, and we aimed to explore the biological function and mechanism of SOX12 in thyroid cancer. Materials and Methods: We first analyzed the expression of...
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MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression

Zhang Z, Zhu X

Purpose: Our research aimed to investigate the influence of miR-103a-3p on the growth and apoptosis of colorectal cancer (CRC) cells. Materials and Methods: Bioinformatics was employed to analyze differentially expressed microRNAs...
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Gymnemic Acid Ameliorates Pancreatic β-Cell Dysfunction by Modulating Pdx1 Expression: A Possible Strategy for β-Cell Regeneration

Kannan P, Raghunathan M, Mohan T, Palanivelu S, Periandavan K

BACKGROUND: Endogenous pancreatic β-cell regeneration is a promising therapeutic approach for enhancing β-cell function and neogenesis in diabetes. Various findings have reported that regeneration might occur via stimulating β-cell proliferation,...
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Insulin enhances neurite extension and myelination of diabetic neuropathy neurons

Pham VM, Thakor N

Background: The authors established an In Vitro model of diabetic neuropathy based on the culture system of primary neurons and Schwann cells (SCs) to mimic similar symptoms observed in in...
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Unilateral Orbital Lipoma in Young Woman Occurred 5 Years after Autologous Fat-graft

Kim TH, Lee SU, Lee SJ, Kim CZ

Purpose: To report a case of unilateral orbital lipoma in a 22-year-old woman after an autologous fat graft. Case summary: A 22-year-old woman visited our clinic with the chief complaint of...
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An Adenocarcinoma Associated with Bilateral, Diffuse, Uveal Melanocytic Proliferation

Chung W, Kim SH, Choi Y, Choi SK, Lee JJ, Park SW, Byon IS

Purpose: We report bilateral, diffuse, uveal melanocytic proliferation caused by a stomach adenocarcinoma. Case summary: A 78-year-old male complained of visual impairment 3 months in duration. He had diabetes and had...
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Bizarre Parosteal Osteochondromatous Proliferation of the Proximal Phalanx of the Great Toe: A Case Report

Kim K, Kim YM, Han WC, Han B

Nora et al. first reported a bizarre parostealosteochondromatous proliferation (BPOP) as a small size bone malformation mainly in the foot and hand in April 1983 that was called Nora’s lesion...
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Sex Comb on Midleg Like-2 Accelerates Hepatocellular Carcinoma Cell Proliferation and Metastasis by Activating Wnt/β-Catenin/EMT Signaling

Du L, Wang L, Yang H, Duan J, Lai J, Wu W, Fan S, Zhi X

Purpose: The purpose of this study was to investigate the influences of sex comb on midleg like-2 (SCML2) on hepatocellular carcinoma (HCC) and potentially related mechanisms. Materials and Methods: SCML2 expression...
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Role of NEAT1/MiR-9-5p/SLC26A2 Pathway on Human Airway Smooth Muscle Cell

Wang X, Xu R, Chi D, Dai C, Sheng M

Purpose: Asthma is a serious inflammatory disease of the respiratory system in which airway smooth muscle cells (ASMCs) play a key role. This study aimed to investigate the expression of...
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Histopathological Analysis of Esophageal Mucosa in Patients with Achalasia

Lee BE, Kim GH, Shin N, Park DY, Song GA

Background/Aims: Achalasia is an esophageal motor disorder that leads to functional esophageal obstruction. Food stasis and bacterial fermentation can predispose an individual to esophageal mucosal inflammation, causing multifocal dysplasia and...
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AC092127.1-miR-451a-AE binding protein 2 Signaling Facilitates Malignant Properties of Breast Cancer

Zhang X, Cong L, Xu D, Leng Q, Shi M, Zhou Y

Purpose: The purpose of the current study was to explore the functions and potential mechanism of miR-451a in breast cancer (BC). Methods: Quantitative reverse transcription real-time polymerase chain reaction was used...
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The Role of miR-34c-5p in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

Liu B, Gan W, Jin Z, Wang M, Cui G, Zhang H, Wang H

Background and Objectives: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a critical role in the success of lumbar spinal fusion with autogenous bone graft. This study aims...
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Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling

Cao YY, Wang ZH, Xu QC, Chen Q, Wang Z, Lu WH

The intestinal barrier function disrupted in sepsis, while little is known about the variation in different phases of sepsis. In this study, mouse models of sepsis were established by caecal...
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Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/ SOCS1 Axis

Liu W, Zhou X, Li Y, Jiang H, Chen A

Purpose: Non-coding RNA activated by DNA damage (NORAD) has been reported to be a cancer-related long non-coding RNA (lncRNA) implicated in the progression of several cancers; however, its role in...
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Signaling Role of Adipocyte Leptin in Prostate Cell Proliferation Induced by Trichomonas vaginalis

Kim JH, Han IH, Shin SJ, Park SY, Chung HY, Ryu JS

Leptin is a type of adipokine mainly produced by adipocytes and reported to be overproduced in prostate cancer. However, it is not known whether it stimulates the proliferation of prostate...
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Role of IFNLR1 gene in PRRSV infection of PAM cells

Qin M, Chen W, Li Z, Wang L, Ma L, Geng J, Zhang Y, Zhao J, Zeng Y

Background: Interferon lambda receptor 1 (IFNLR1) is a type II cytokine receptor that clings to interleukins IL-28A, IL29B, and IL-29 referred to as type III IFNs (IFN-λs). IFN-λs act through...
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SP-8356, a (1S)-(-)-Verbenone Derivative, Inhibits the Growth and Motility of Liver Cancer Cells by Regulating NF-κB and ERK Signaling

Kim DH, Yong HJ, Mander S, Nguyen HT, Nguyen LP, Park HK, Cha HK, Kim WK, Hwang JI

Liver cancer is a common tumor and currently the second leading cause of cancer-related mortality globally. Liver cancer is highly related to inflammation as more than 90% of liver cancer...
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Inhibition of MUC1-C Increases ROS and Cell Death in Mouse Embryonic Stem Cells

Park JA, Park S, Choi JK, Han MK, Lee Y

Background and Objectives: Embryonic stem (ES) cells have the capacity to self-renew and generate all types of cells. MUC1-C, a cytoplasmic subunit of MUC1, is overexpressed in various carcinomas and mediates...
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