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Role of NEAT1/MiR-9-5p/SLC26A2 Pathway on Human Airway Smooth Muscle Cell

Wang X, Xu R, Chi D, Dai C, Sheng M

Purpose: Asthma is a serious inflammatory disease of the respiratory system in which airway smooth muscle cells (ASMCs) play a key role. This study aimed to investigate the expression of...
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Histopathological Analysis of Esophageal Mucosa in Patients with Achalasia

Lee BE, Kim GH, Shin N, Park DY, Song GA

Background/Aims: Achalasia is an esophageal motor disorder that leads to functional esophageal obstruction. Food stasis and bacterial fermentation can predispose an individual to esophageal mucosal inflammation, causing multifocal dysplasia and...
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AC092127.1-miR-451a-AE binding protein 2 Signaling Facilitates Malignant Properties of Breast Cancer

Zhang X, Cong L, Xu D, Leng Q, Shi M, Zhou Y

Purpose: The purpose of the current study was to explore the functions and potential mechanism of miR-451a in breast cancer (BC). Methods: Quantitative reverse transcription real-time polymerase chain reaction was used...
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The Role of miR-34c-5p in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

Liu B, Gan W, Jin Z, Wang M, Cui G, Zhang H, Wang H

Background and Objectives: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a critical role in the success of lumbar spinal fusion with autogenous bone graft. This study aims...
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Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling

Cao YY, Wang ZH, Xu QC, Chen Q, Wang Z, Lu WH

The intestinal barrier function disrupted in sepsis, while little is known about the variation in different phases of sepsis. In this study, mouse models of sepsis were established by caecal...
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Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/ SOCS1 Axis

Liu W, Zhou X, Li Y, Jiang H, Chen A

Purpose: Non-coding RNA activated by DNA damage (NORAD) has been reported to be a cancer-related long non-coding RNA (lncRNA) implicated in the progression of several cancers; however, its role in...
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Signaling Role of Adipocyte Leptin in Prostate Cell Proliferation Induced by Trichomonas vaginalis

Kim JH, Han IH, Shin SJ, Park SY, Chung HY, Ryu JS

Leptin is a type of adipokine mainly produced by adipocytes and reported to be overproduced in prostate cancer. However, it is not known whether it stimulates the proliferation of prostate...
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Role of IFNLR1 gene in PRRSV infection of PAM cells

Qin M, Chen W, Li Z, Wang L, Ma L, Geng J, Zhang Y, Zhao J, Zeng Y

Background: Interferon lambda receptor 1 (IFNLR1) is a type II cytokine receptor that clings to interleukins IL-28A, IL29B, and IL-29 referred to as type III IFNs (IFN-λs). IFN-λs act through...
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SP-8356, a (1S)-(-)-Verbenone Derivative, Inhibits the Growth and Motility of Liver Cancer Cells by Regulating NF-κB and ERK Signaling

Kim DH, Yong HJ, Mander S, Nguyen HT, Nguyen LP, Park HK, Cha HK, Kim WK, Hwang JI

Liver cancer is a common tumor and currently the second leading cause of cancer-related mortality globally. Liver cancer is highly related to inflammation as more than 90% of liver cancer...
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Inhibition of MUC1-C Increases ROS and Cell Death in Mouse Embryonic Stem Cells

Park JA, Park S, Choi JK, Han MK, Lee Y

Background and Objectives: Embryonic stem (ES) cells have the capacity to self-renew and generate all types of cells. MUC1-C, a cytoplasmic subunit of MUC1, is overexpressed in various carcinomas and mediates...
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Predictor of Subungual Melanoma against Benign Longitudinal Melanonychia: A Retrospective Cohort Study from Korea

Yim SH, Kwon IS, Hong D, Jung KE, Lee Y, Seo YJ, Choi CW

Background: Longitudinal melanonychia (LM) is a common clinical finding. Most cases of LM are benign, and a waitand-see approach is preferred in the management of this condition. Nevertheless, it is...
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Vinpocetine inhibits the proliferation and induces apoptosis in human colon cancer cells

Kim MK, Park HJ, Kim Y, Kim YI, Bae SK, Kim HJ, Bae MK

Vinpocetine induces anti-inflammatory effects in various inflammatory diseases via the inhibition of phosphodiesterase type-1-independent nuclear factor-κB signaling pathway and the release of inflammatory cytokines. In this study, we investigated the...
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Anti-proliferative and apoptotic effects of hull-less pumpkin extract on human papillary thyroid carcinoma cell line

Bahadori MH, Azari Z, Zaminy A, Dabirian S, Mehrdad SM, Kondori BJ

Papillary thyroid carcinoma (PTC) is one of the most common cancers of the endocrine system. Previous studies have shown that the extract of hull-less pumpkin seed (HLPS) has a significant...
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Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis

Zhao X, Xing J, Li J, Hou R, Niu X, Liu R, Jiao J, Yang X, Li J, Liang J, Zhou L, Wang Q, Chang W, Yin G, Li X, Zhang K

Background and Objectives: Psoriasis is a chronic inflammatory skin disease, which the mechanisms behind its initiation and development are related to many factors. DMSCs (dermal mesenchymal stem cells) represent an...
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Modulation of Vascular Smooth Muscle Cell Phenotype by High Mobility Group AT-Hook 1

Jung Y, Lee HS, Ha JM, Jin SY, Kum HJ, Vafaeinik F, Ha HK, Song SH, Kim CD, Bae SS

Objective: The purpose of this study is to examine the effect of high mobility group AT-hook 1 (HMGA1) on the phenotyptic change of vascular smooth muscle cells (VSMCs). Methods: Gene silencing...
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The proper concentrations of dextrose and lidocaine in regenerative injection therapy: in vitro study

Woo MS, Park J, Ok SH, Park M, Sohn JT, Cho MS, Shin IW, Kim YA

Background: Prolotherapy is a proliferation therapy as an alternative medicine. A combination of dextrose solution and lidocaine is usually used in prolotherapy. The concentrations of dextrose and lidocaine used in...
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Two intertwined compartments coexisting in sporadic conventional colon adenomas

Rubio CA

Sporadic conventional colon adenomas are microscopically built of 2 intertwined compartments: one on top, harboring the dysplastic tissue that defines their histo-biomolecular attributes, and the other below, composed of non-dysplastic...
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Tumor associated mast cells: biological roles and therapeutic applications

Saxena S, Singh A, Singh P

Mast cells (MCs) are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of MCs significantly modulates many aspects of...
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Activation of AMPK by Telmisartan Decreases Basal and PDGF-stimulated VSMC Proliferation via Inhibiting the mTOR/p70S6K Signaling Axis

Hwang YJ, Park JH, Cho DH

Background: Telmisartan, an angiotensin II type 1 receptor blocker (ARB), is widely used to treat hypertension by blocking the renin-angiotensin-aldosterone system. Although abnormal proliferation of vascular smooth muscle cells (VSMCs)...
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Epigenetically Upregulated T-Type Calcium Channels Contribute to Abnormal Proliferation of Embryonic Neural Progenitor Cells Exposed to Valproic Acid

Kim JW, Oh HA, Kim SR, Oh MJ, Seung H, Lee SH, Shin SH

Valproic acid is a clinically used mood stabilizer and antiepileptic drug. Valproic acid has been suggested as a teratogen associated with the manifestation of neurodevelopmental disorders, such as fetal valproate...
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