Clin Psychopharmacol Neurosci.  2020 Feb;18(1):159-163. 10.9758/cpn.2020.18.1.159.

Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series

  • 1Departments of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
  • 2Departments of Clinical Pharmacy, Fujita Health University School of Medicine, Toyoake, Japan
  • 3Office of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy, Meijo University, Nagoya, Japan


In Japan, drug therapy for schizophrenia is characterized by high-dose antipsychotic polypharmacy, which is an uncommon approach internationally. In this study, we reduced the number of antipsychotic agents in 5 patients using the Safety Correction of High-dose Antipsychotic Polypharmacy (SCAP) method and conducted a survey regarding treatment satisfaction. The switch from polypharmacy to monotherapy was achieved in all patients. There was no deterioration in psychiatric symptoms, and adverse reactions were reduced. Three of the subjects were satisfied with the decrease in the number of antipsychotic agents and dose-reduction. These results suggest that the SCAP method is a safe and useful method that can be applied in a clinical setting.


Schizophrenia; Antipsychotic agents; Polypharmacy; Patient satisfaction
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