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Consideration of Long-Acting Injectable Antipsychotics for Polypharmacy Regimen in the Treatment of Schizophrenia: Put It on the Table or Not?

Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

Antipsychotic monotherapy (APM) is considered best-acceptable treatment option regardless of antipsychotic class and formulation types for treating schizophrenia. However, antipsychotic polypharmacy (APP) has been also widely utilized in routine clinical...
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Clinical Benefit and Utility of Switching to Aripiprazole Once Monthly in Patients with Antipsychotic Polypharmacy or Long Acting Injectable Antipsychotics for Patients with Schizophrenia in Routine Practice: A Retrospective, Observation Study

Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

Objective: In a number of controlled clinical trials and naturalistic studies, aripiprazole once monthly (AOM) has been found to be effective and safe as acute and maintenance treatment options for...
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Change of Prescribing Pattern after Clozapine Discontinuation: A Retrospective Chart Review

Kang SH

Objectives: Despite the high discontinuation rate of clozapine in refractory schizophrenia, there is limited evidence regarding the suggested treatment after clozapine discontinuation. Methods: The medical records of 37 patients who discontinued...
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Combined Medication with Stimulants and Non-stimulants for Attention-deficit/hyperactivity Disorder

Bahn GH, Seo K

Objective: To study the efficiency and indication of combined medication with a stimulant and non-stimulant for attention-deficiency/hyperactivity disorder (ADHD), herein, the authors examined children and adult patients with ADHD. Methods: Subjects...
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Exploring Hidden Issues in the Use of Antipsychotic Polypharmacy in the Treatment of Schizophrenia

Kim JJ, Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

The mainstay of schizophrenia treatment is pharmacological therapy using various antipsychotics including first- and second-generation antipsychotics which have different pharmacokinetic and pharmacodynamic property leading to differential presentation of adverse events...
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A Call for a Rational Polypharmacy Policy: International Insights From Psychiatrists

Nakagami Y, Hayakawa K, Horinouchi T, Pereira-Sanchez V, Tan MP, Park SC, Park YC, Moon SW, Choi TY, Avasthi A, Grover S, Kallivayalil RA, Rai Y, Shalbafan M, Chongsuksiri P, Udomratn P, Kathriarachchi ST, Xiang YT, Sim K, Javed A, Chong MY, Tan CH, Lin SK, Inada T, Murai T, Kanba S, Sartorius N, Shinfuku N, Kato TA

Objective Recently, rational polypharmacy approaches have been proposed, regardless of the lower risk and cost of monotherapy. Considering monotherapy as first-line treatment and polypharmacy as rational treatment, a balanced attitude...
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Prescription Pattern of 1 Year Clozapine Maintenance and Augmentation Agents in Schizophrenia Spectrum Disorders

Kim J, Kim SH, Jang JH, Moon SY, Kang TU, Kim M, Kwon JS

Objectives Clozapine is the most effective atypical antipsychotic agent for the treatment-resistant schizophrenia (TRS), however, only 40%–70% of TRS patients respond to clozapine. Moreover, TRS encompasses various symptom dimensions. Therefore,...
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Comedications and potential drug-drug interactions with direct-acting antivirals in hepatitis C patients on hemodialysis

Hsu PY, Wei YJ, Lee JJ, Niu SW, Huang JC, Hsu CT, Jang TY, Yeh ML, Huang CI, Liang PC, Lin YH, Hsieh MY, Hsieh MH, Chen SC, Dai CY, Lin ZY, Chen SC, Huang JF, Chang JM, Hwang SJ, Chuang WL, Huang CF, Chiu YW, Yu ML

Background/Aims: Direct‐acting antivirals (DAAs) have been approved for hepatitis C virus (HCV) treatment in patients with end-stage renal disease (ESRD) on hemodialysis. Nevertheless, the complicated comedications and their potential drug-drug...
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Antipsychotic Polypharmacy in Treatment of Schizophrenia; Should or Should Not?

Pae CU

Antipsychotics have been utilized as the standard treatment for schizophrenia regardless of illness phase where antipsychotic monotherapy (APM) is routinely recommended as the gold standard rather than antipsychotic polypharmacy (APP)....
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All about pain pharmacology: what pain physicians should know

Kim KH, Seo HJ, Abdi S, Huh B

From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of...
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Prevalence and Predictors of Polypharmacy among Elderly Outpatients in a Public Hospital

Koo HJ, Kim MJ, Park H, Chae J, Kim J, Park KH, Kim M

Background: Polypharmacy, the use of multiple drugs, is a growing concern in older adults. It has been reported that the prevalence of polypharmacy in elderly patients is higher in Korea...
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Nutrient intakes and medication use in elderly individuals with and without dry mouths

Lee KA, Park JC, Park YK

BACKGROUND/OBJECTIVES: The nutrition of the elderly depends on various factors. Oral health, especially oral dryness, can be an important risk factor. In this study, we attempted to determine whether dry...
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Anticholinergic Cognitive Burden as a Predictive Factor for In-hospital Mortality in Older Patients in Korea

Lee JH, Jung HW, Jang IY, Moon Sd, Lee S, Han SJ

Background: With the increasing prevalence of chronic disease due to aging, many older adults experience multimorbidity and polypharmacy. Medications with anticholinergic properties are particularly associated with adverse cognitive outcomes, including...
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Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series

Kamei H, Yamada H, Hatano M, Hanya M, Yamada S, Iwata N

In Japan, drug therapy for schizophrenia is characterized by high-dose antipsychotic polypharmacy, which is an uncommon approach internationally. In this study, we reduced the number of antipsychotic agents in 5...
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Effectiveness and Tolerability of Switching to Aripiprazole Once Monthly from Antipsychotic Polypharmacy and/or Other Long Acting Injectable Antipsychotics for Patients with Schizophrenia in Routine Practice: A Retrospective, Observation Study

Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

Objective: This study was done for collection of real world data of Aripiprazole Once Monthly (AOM) in patients with schizophrenia. Methods: The observation was up to 12 months from the first...
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Polypharmacy in Geriatrics and Beers Criteria

Kim JH, Lee SH

As life expectancy increases, the number of elderly people with chronic diseases has been gradually increasing. As a result, the number of drugs taken has also increased. The purpose of...
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Association between Full Electronic Medical Record System Adoption and Drug Use: Antibiotics and Polypharmacy

Park YT, Kim D, Park RW, Atalag K, Kwon IH, Yoon D, Choi M

OBJECTIVES: We investigated associations between full Electronic Medical Record (EMR) system adoption and drug use in healthcare organizations (HCOs) to explore whether EMR system features such as electronic prescribing, medicines...
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Examining Patterns of Polypharmacy in Bipolar Disorder: Findings from the REAP-BD, Korea

Kim K, Yang H, Na E, Lee H, Jang OJ, Yoon HJ, Oh HS, Ham BJ, Park SC, Lin SK, Tan CH, Shinfuku N, Park YC

Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical...
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Polypharmacy is a risk factor for disease flare in adult patients with ulcerative colitis: a retrospective cohort study

Wang J, Nakamura T, Tuskey AG, Behm BW

BACKGROUND/AIMS: Polypharmacy is a common clinical problem with chronic diseases that can be associated with adverse patient outcomes. The present study aimed to determine the prevalence and patient-specific characteristics associated...
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The Need for Actions Against Polypharmacy in Older People With Frailty

Kojima T

Providing safe and effective drug therapy to older patients is challenging for physicians since there is not sufficient evidence to support the efficacy of these drugs and this population is...
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