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Effectiveness in Switching from Antipsychotic Polypharmacy to Monotherapy in Patients with Schizophrenia: A Case Series

Kamei H, Yamada H, Hatano M, Hanya M, Yamada S, Iwata N

In Japan, drug therapy for schizophrenia is characterized by high-dose antipsychotic polypharmacy, which is an uncommon approach internationally. In this study, we reduced the number of antipsychotic agents in 5...
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Effect of Scopolamine Butylbromide on Clozapine-induced Hypersalivation in Schizophrenic Patients: A Case Series

Takeuchi I, Suzuki T, Kishi T, Kanamori D, Hanya M, Uno J, Fujita K, Kamei H

Clozapine has been demonstrated to be useful for treating refractory schizophrenia. However, hypersalivation occurs in 31.0-97.4% of the patients treated with clozapine. Accordingly, some patients who are disturbed by their...
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Effect of Adenine on Clozapine-induced Neutropenia in Patients with Schizophrenia: A Preliminary Study

Takeuchi I, Kishi T, Hanya M, Uno J, Fujita K, Kamei H

OBJECTIVE: This study examined the utility of adenine for preventing clozapine-induced neutropenia. METHODS: This retrospective study examined the effect of adenine on clozapine-induced neutropenia in patients with treatment-resistant schizophrenia and was...
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Acceptance of the Deltoid Muscle Injection of Aripiprazole Long-acting Injectable in the Patients with Schizophrenia

Kamei H, Homma Y, Takeuchi I, Hajitsu G, Tozawa K, Hatano M, Fukui A, Hanya M, Yamada S, Iwata N

Objective: To improve poor medication adherence in schizophrenic patients, long-acting injectable (LAI) antipsychotics are used. However, it has not yet become common in Japan. Recently, aripiprazole LAI was approved for...
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Assessment of Switching to Suvorexant versus the Use of Add-on Suvorexant in Combination with Benzodiazepine Receptor Agonists in Insomnia Patients: A Retrospective Study

Hatano M, Kamei H, Inagaki R, Matsuzaki , Hanya M, Yamada S, Iwata N

OBJECTIVE: Suvorexant is a novel hypnotic drug that does not interact with the conventional γ-aminobutyric acid (GABA)-A receptor. We investigated the method by which suvorexant was introduced in insomnia patients...
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Satisfaction Survey on Antipsychotic Formulations by Schizophrenia Patients in Japan

Hatano M, Takeuchi I, Yamashita K, Morita A, Tozawa K, Sakakibara T, Hajitsu G, Hanya M, Yamada S, Iwata N, Kamei H

Objective: To identify factors affecting adherence to medication, a subjective questionnaire survey was administered to schizophrenia patients regarding the prescribed antipsychotic formulations. Methods: We evaluated the patients’ satisfaction and dissatisfaction with...
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A Questionnaire-based Study of the Views of Schizophrenia Patients and Psychiatric Healthcare Professionals in Japan about the Side Effects of Clozapine

Takeuchi I, Hanya M, Uno J, Amano Y, Fukai K, Fujita K, Kamei H

OBJECTIVE: It is well documented that clozapine treatment causes agranulocytosis, but it can also induce drowsiness, constipation, and hypersalivation; however, these symptoms are usually less severe. It has been reported...
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Assessment of the Latent Adverse Events of Antipsychotic Treatment Using a Subjective Questionnaire in Japanese Patients with Schizophrenia

Hatano M, Kamei H, Kato A, Takeuchi I, Hanya M, Uno J, Yamada S, Fujita K, Iwata N

OBJECTIVE: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we investigated the adverse events of antipsychotics that are less likely to...
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