J Audiol Otol.  2020 Apr;24(2):53-60. 10.7874/jao.2020.00115.

Experimental Animal Models for Meniere’s Disease:A Mini-Review

Affiliations
  • 1Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Korea
  • 2Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, Korea
  • 3School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, WA, Australia

Abstract

Several novel animal models that represent the pathophysiological process of endolymphatic hydrops (ELH) of Meniere’s disease (MD) have been developed. Animal models are important to identify and characterize the pathophysiology of ELH and to corroborate molecular and genetic findings in humans. This review of the current animal models will be useful in understanding the pathophysiology of and developing proper treatments for MD. Surgical animal models will be replaced by medication-induced animal models. Study models previously developed in guinea pigs will be developed in several smaller animals for ease of conducting molecular analysis. In this review, we provided updated resources including our previous studies regarding the current and desirable animal models for MD. J Audiol Otol 2020;24(2):53-60

Keyword

Endolymphatic hydrops; Meniere’s disease; Animal model; Endolymphatic sac; Lipopolysaccharide
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