Korean J Audiol.  2013 Apr;17(1):9-12. 10.7874/kja.2013.17.1.9.

Development of Animal Models of Otitis Media

• Park MK
• Lee BD

• KMID: 2039495
• DOI: http://doi.org/10.7874/kja.2013.17.1.9

Abstract

Otitis media is defined as inflammation of the middle ear, including the auditory ossicles and the Eustachian tube. Otitis media is a major health problem in many societies. The causes of otitis media includes infection and anatomic/physiologic, host, and environmental factors. In general, otitis media is a childhood disease, and anatomic and physiologic changes have great effects on its development. Thus, in vitro or human experimental studies of otitis media are difficult. Several experimental animal models have been introduced to investigate the pathogenesis and treatment of otitis media. However, none are ideal. The aim of this review is to provide a brief overview of the current status of animal models of otitis media with effusion, acute otitis media, and cholesteatoma. This review will assist determination of the most appropriate animal models of otitis media.

Keyword

Otitis media; Cholesteatoma; In vitro; Animal model

MeSH Terms

Animals
Cholesteatoma
Ear Ossicles
Ear, Middle
Eustachian Tube
Humans
Inflammation
Models, Animal
Otitis
Otitis Media
Otitis Media with Effusion