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Validation of the Osteomyelitis Induced by Methicillin-Resistant Staphylococcus aureus (MRSA) on Rat Model with Calvaria Defect

Choi YS, Ham DS, Lim JY, Lee YK

Background: Osteomyelitis resulting from bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to multiple drugs, brings further clinical challenges. There is currently no model of osteomyelitis induced by...
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Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model

Doostkam A, Mirkhani H, Iravani K, Karbalay-Doust S, Zarei K

Objectives. Diabetic auditory neuropathy is a common complication of diabetes mellitus that has a major impact on patients’ quality of life. In this study, we assessed the efficacy of rutin...
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Freeze-dried bovine amniotic membrane as a cell delivery scaffold in a porcine model of radiation-induced chronic wounds

Oh D, Son D, Kim J, Kwon SY

Background Locoregional stem cell delivery is very important for increasing the efficiency of cell therapy. Amnisite BA (Amnisite) is a freeze-dried amniotic membrane harvested from bovine placenta. The objective of...
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Dedicated Cold Snare vs. Traditional Snare for Polypectomy of Diminutive and Small Lesions in a Porcine Model: A Research Group for Endoscopic Instruments and Stents (REIS) Study

Lee HH, Lee BI, Kim JW, Lim H, Lee SH, Cho JH, Jung Y, Kim KO, Kim CG, Lee KM, Park JJ, Choi MG, Chun HJ, Kim HG

Background/Aims: The aim of this in vivo animal study was to evaluate the effectiveness and safety of dedicated cold snare (DCS) compared with those of traditional snare (TS) for cold...
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Inner Ear Gene Therapy in Mouse Models of Genetic Hearing Loss

Choi JW

Hearing loss is the most frequent sensory disorder affecting newborns and children. About 1 newborn in every 500 suffer from congenital hearing loss, with approximately half of these having a...
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Nonhuman primate model in mammary gland biology and neoplasia research

Dewi FN, Cline JM

Research on breast cancer pathogenesis, prevention and drug development remains an important field as this disease is still one of the leading causes of cancer death worldwide. Nonhuman primates, particularly...
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Novel Animal Model of Oral Dysphagia Following Hemiglossectomy

Kim MJ, Tri HM, Kim JM, Choi ME, Kim YM, Choi JS, Kim JW

Objective: This study aimed to establish an animal model of oral dysphagia for translational research purposes. Methods: Four week old C57BL/6 mice were randomized to a surgical partial glossectomy group (horizontal...
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Maladaptive Alterations of Defensive Response Following Developmental Complex Stress in Rats

Kim J, Park M, Lee C, Ha JJ, Choi JS, Kim CH, Seok JH

Objective: Despite the etiological significance of complex developmental trauma in adult personality disorders and treatment-resistant depression, neurobiological studies have been rare due to the lack of useful animal models. As...
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Development of a standardized mucositis and osteoradionecrosis animal model using external radiation

Seo MH, Lee MY, Eo MY, Lee SK, Woo KM, Kim SM

Objectives: Although the side effects of radiation therapy vary from mucositis to osteomyelitis depending on the dose of radiation therapy, to date, an experimental animal model has not yet been...
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Skin Exposure Contributes to Chemical-Induced Asthma: What is the Evidence? A Systematic Review of Animal Models

Tsui HC, Ronsmans S, Sadeleer L, Hoet PHM, Nemery B, Vanoirbeek JAJ

It is generally assumed that allergic asthma originates primarily through sensitization via the respiratory mucosa, but emerging clinical observations and experimental studies indicate that skin exposure to low molecular weight...
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Highlights on selected microscopy techniques to study zebrafish developmental biology

Abu-Siniyeh A, Al-Zyoud W

Bio-imaging is a tedious task when it concerns exploring cell functions, developmental mechanisms, and other vital processes in vivo. Single-cell resolution is challenging due to different issues such as sample...
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Animal models for the risk assessment of viral pandemic potential

Park MS, Kim JI, Bae JY, Park MS

Pandemics affect human lives severely and globally. Experience predicts that there will be a pandemic for sure although the time is unknown. When a viral epidemic breaks out, assessing its...
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COVID-19 and veterinarians for one health, zoonotic- and reverse-zoonotic transmissions

Yoo HS, Yoo D

A novel coronavirus emerged in human populations and spread rapidly to cause the global coronavirus disease 2019 pandemic. Although the origin of the associated virus (severe acute respiratory syndrome coronavirus...
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Experimental Animal Models for Meniere’s Disease:A Mini-Review

Seo YJ, Brown D

Several novel animal models that represent the pathophysiological process of endolymphatic hydrops (ELH) of Meniere’s disease (MD) have been developed. Animal models are important to identify and characterize the pathophysiology of ELH...
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Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models

Mizoguchi , Low D, Ezaki Y, Okada T

The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease...
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Characterization of aged male BALB/ccenp mice as a model of dementia

Esquivel N, García Y, Lores B, Gutiérrez M, Rodríguez C

Dementia is defined as cognitive impairment in more than one cognitive area and leads to an abnormal degree of impairment in the ability to remember past events. Among mice models...
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Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model

Khalmuratova R, Lee M, Park JW, Shin HW

PURPOSE: Osteitis refers to the development of new bone formation and remodeling of bone in chronic rhinosinusitis (CRS) patients; it is typically associated with eosinophilia, nasal polyps (NPs), and recalcitrant...
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Therapeutic Efficacy of Bone Marrow Derived Mesenchymal Stem Cells in Ototoxic Sensorineural Hearing Loss

Kim S, Kwon YH, Kim IB, Seo YJ, Han JS, Seo JH, Lee HJ, Park KH

Background and Objectives Ototoxic sensorineural hearing loss causes permanent hearing loss in most cases. Recently there have been many reports describing cell base therapy with stem cells that has some...
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Refining drug administration in a murine model of acute infection with Trypanosoma cruzi

Nicolás Gulin JE, Bisio M, García-Bournissen F

Background: In animal research, “refinement” refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Evaluation of drug efficacy in mice...
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Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing

Camstra KM, Srinivasan VM, Collins D, Chen S, Kan P, Johnson J

Purpose: With advancing endovascular technology and increasing interest in minimally invasive intra-arterial therapies such as stem cell and chemotherapy for cerebral disease, the establishment of a translational model with cerebral...
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