Res Vestib Sci.  2016 Sep;15(3):65-69. 10.0000/rvs.2016.15.3.65.

A History for Experimental Animal Models of Endolymphatic Hydrops

• Kim HJ
• Kim KS

• KMID: 2351568
• DOI: http://doi.org/10.0000/rvs.2016.15.3.65

Abstract

It is known that endolymphatic hydrops is a pathophysiologic mechanism of Meniere's disease, while the detailed role is not fully clarified. Study for endolymphatic hydrops mainly represents a pathologic histologic finding found only in the post-mortem examination of temporal bone, so endolymphatic hydrops animal models have played important role in terms of understanding how hydrops affects the function of the inner ear. Numerous challenges with diverse animals and techniques have been tried to reveal the possible pathophysiology of endolymphatic hydrops and develop an effective treatment. This review shows historical background and technical advances in experimental animal model for endolymphatic hydrops and Meniere's disease.

Keyword

Meniere disease; Endolymphatic hydrops; Animal model

MeSH Terms

Animals
Autopsy
Ear, Inner
Edema
Endolymphatic Hydrops*
Meniere Disease
Models, Animal*
Temporal Bone