Res Vestib Sci.  2016 Dec;15(4):95-100. 10.21790/rvs.2016.15.4.95.

Experiemental Model for Ménière's Disease Using Surgical Ablation of Endolymphatic Sac

• Kim M
• Kim MJ

• KMID: 2362282
• DOI: http://doi.org/10.21790/rvs.2016.15.4.95

Abstract

Endolymphatic hydrops is a representing pathologic finding of Ménière's disease. For the induction of endolymphatic hydrops in an animal model, surgical ablation of endolymphatic sac has been used. Although traditional model with the blockage of endolymphatic sac induced severe hydrops, it has several limitations for the study of pathophysiology of Ménière's disease. Recently, modified experimental models have been introduced, in which additional procedure was performed to induce the acute aggravation of hydrops after the surgical ablation. These new models could be helpful to elucidate the mechanism and develop a new treatment of Ménière's disease. In this review, we introduce the characteristics of animal models using surgical ablation of endolymphatic sac from the classical model to novel modified models.

Keyword

Meniere disease; Endolymphatic hydrops; Animal model

MeSH Terms

Edema
Endolymphatic Hydrops
Endolymphatic Sac*
Meniere Disease*
Models, Animal
Models, Theoretical