Nucl Med Mol Imaging.
2020 Apr;54(2):86-97. 10.1007/s13139-020-00640-z.
Preclinical Voxel-Based Dosimetry in Theranostics: a Review
- Affiliations
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- 1Department of Radiology & Imaging, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
- 2Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA
- 3Center for Ionizing Radiation, Korea Research Institute of Standards and Science, Daejeon, South Korea
- 4Department of Nuclear Medicine, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 03080, South Korea
- 5Interdisciplinary Program in Radiation Applied Life Science, Seoul National University, Seoul, South Korea
- 6Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, South Korea
- KMID: 2500062
- DOI: http://doi.org/10.1007/s13139-020-00640-z
Abstract
- Due to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the development of novel theranostic agents, several studies have been performed to accurately estimate absorbed doses to mice at the voxel level using reference mouse phantoms and Monte Carlo (MC) simulations. Accurate dosimetry is important in preclinical theranostics to interpret radiobiological dose-response relationships and to translate results for clinical use. Direct MC (DMC) simulation is believed to produce more realistic voxel-level dose distribution with high precision because tissue heterogeneities and nonuniform source distributions in patients or animals are considered. Although MC simulation is considered to be an accurate method for voxelbased absorbed dose calculations, it is time-consuming, computationally demanding, and often impractical in daily practice. In this review, we focus on the current status of voxel-based dosimetry methods applied in preclinical theranostics and discuss the need for accurate and fast voxel-based dosimetry methods for pretherapy absorbed dose calculations to optimize the dose computation time in preclinical TRT.
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