J Korean Thyroid Assoc.  2013 May;6(1):43-48. 10.11106/jkta.2013.6.1.43.

Methods and Clinical Efficacy of Dosimetry-Based Treatment in Radioiodine Therapy of Thyroid Cancer

• Paeng JC
• Chung JK

• KMID: 1428452
• DOI: http://doi.org/10.11106/jkta.2013.6.1.43

Abstract

Radioiodine (RI) therapy is one of the key factors for the good prognosis of differentiated thyroid cancers. Currently, most of RI treatments are performed with predetermined fixed dose of RI, whereas strict dose adjustment is made in chemotherapy or external radiotherapy for cancer treatment. Although fixed dose methods have been practically effective in RI therapy hitherto, dose determination with individual radiation dosimetry is theoretically superior to use of empirical fixed dose, for maximization of treatment effect and minimization of adverse events. The theoretical superiority of dosimetry-based dose determination is not yet directly supported by clinical data of real world; however, indirect results support the use of dosimetry-based dose determination in several specific patient groups. In this review, the basis of dosimetry is briefly discussed with regard to necessity and practical methods. Additionally, the efficacy of dosimetry is also discussed through the data of clinical studies so far.

Keyword

Thyroid cancer; Radioiodine; Dosimetry; Fixed dose

MeSH Terms

Humans
Prognosis
Radiometry
Thyroid Gland
Thyroid Neoplasms