- Anesthesia and analgesia for common research models of adult mice
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Ahmadi‑Noorbakhsh S, Abbasi M, Ghasemi M, Bayat G, Davoodian N, Sharif‑Paghaleh E, Poormoosavi S, Rafizadeh M, Maleki M, Shirzad‑Aski H, Jahromi H, Dadkhah M, Khalvati B, Safari T, Behmanesh M, Khoshnam S, Houshmand G, Talaei S
- KMID: 2537628
- Lab Anim Res.
- 2022 Dec;38(4):271-286.
- doi: 10.1186/s42826-022-00150-3
Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles.... -
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- An exploratory study on the challenges faced and coping strategies used by preclinical medical students during the COVID-19 crisis
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Sam CP, Mamat NH, Nadarajah VD
- KMID: 2530275
- Korean J Med Educ.
- 2022 Jun;34(2):95-106.
- doi: 10.3946/kjme.2022.222
Purpose: The impact of the coronavirus disease 2019 crisis on medical education includes reduced clinical training, a significant loss of learning time and a probable decline in confidence of being... -
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- Quantifying the duration of the preclinical detectable phase in cancer screening: a systematic review
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Geurts SME, Aarts AMWM, Verbeek ALM, Chen THH, Broeders MJM, Duffy SW
- KMID: 2529772
- Epidemiol Health.
- 2022;44(1):e2022008.
- doi: 10.4178/epih.e2022008
OBJECTIVES: The aim of this study was to provide an overview of published mathematical estimation approaches to quantify the duration of the preclinical detectable phase (PCDP) using data from cancer... -
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- Development of Minimally Invasive Mid-infrared Lipolysis Laser System for Effective Fat Reduction
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Lee JY, Ryu HY, Seo YS
- KMID: 2533505
- Med Lasers.
- 2021 Jun;10(2):82-89.
- doi: 10.25289/ML.2021.10.2.82
Background and Objectives Due to changes in diet and lifestyle, the number of obese people worldwide is steadily increasing. Obesity has an adverse effect on a healthy life, so it needs... -
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- Biomarker-Guided Risk Assessment for Acute Kidney Injury: Time for Clinical Implementation?
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Albert C, Haase M, Albert A, Zapf A, Braun-Dullaeus RC, Haase-Fielitz A
- KMID: 2512729
- Ann Lab Med.
- 2021 Jan;41(1):1-15.
- doi: 10.3343/alm.2021.41.1.1
Acute kidney injury (AKI) is a common and serious complication in hospitalized patients, which continues to pose a clinical challenge for treating physicians. The most recent Kidney Disease Improving Global... -
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- Refining drug administration in a murine model of acute infection with Trypanosoma cruzi
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Nicolás Gulin JE, Bisio M, García-Bournissen F
- KMID: 2510415
- Lab Anim Res.
- 2020 Dec;36(4):356-362.
- doi: 10.1186/s42826-020-00071-z
Background: In animal research, “refinement” refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Evaluation of drug efficacy in mice... -
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- In Vitro Modeling of the Tumor Microenvironment in Tumor Organoids
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Devarasetty M, Forsythe SD, Shelkey E, Soker S
- KMID: 2509422
- Tissue Eng Regen Med.
- 2020 Dec;17(6):759-771.
- doi: 10.1007/s13770-020-00258-4
BACKGROUND: The tumor microenvironment (TME) represents the many components occupying the space within and surrounding a tumor, including cells, signaling factors, extracellular matrix, and vasculature. Each component has the potential... -
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- Patient-derived xenografts as compatible models for precision oncology
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Cho SY
- KMID: 2506037
- Lab Anim Res.
- 2020 Jun;36(2):108-118.
- doi: 10.1186/s42826-020-00045-1
Cancer is a very heterogeneous disease, displaying heterogeneity between patients (inter-tumoral heterogeneity) and heterogeneity within a patient (intra-tumoral heterogeneity). Precision oncology is a diagnostic and therapeutic approach for cancers based... -
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- Preclinical Voxel-Based Dosimetry in Theranostics: a Review
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Gupta A, Lee MS, Kim JH, Lee DS, Lee JS
- KMID: 2500062
- Nucl Med Mol Imaging.
- 2020 Apr;54(2):86-97.
- doi: 10.1007/s13139-020-00640-z
Due to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the development of novel theranostic agents, several studies have been performed to accurately estimate absorbed doses to mice... -
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- Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodefi ciency Mice: Preclinical Study
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Quesada MP, GarcÃa-Bernal D, Pastor D, Estirado A, Blanquer M, GarcÃa-Hernández AM, Moraleda J, MartÃnez
- KMID: 2464072
- Tissue Eng Regen Med.
- 2019 Oct;16(5):525-538.
- doi: 10.1007/s13770-019-00202-1
BACKGROUND: Mesenchymal stromal cells (MSCs) have potent immunomodulatory and neuroprotective properties, and have been tested in neurodegenerative diseases resulting in meaningful clinical improvements. Regulatory guidelines specify the need to perform... -
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- Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
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Okada JI, Washio T, Sugiura S, Hisada T
- KMID: 2455805
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):295-303.
- doi: 10.4196/kjpp.2019.23.5.295
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and... -
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- Optical coherence tomography angiography in preclinical neuroimaging
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Choi WJ
- KMID: 2470026
- Biomed Eng Lett.
- 2019 Aug;9(3):311-325.
- doi: 10.1007/s13534-019-00118-8
Preclinical neuroimaging allows for the assessment of brain anatomy, connectivity, and function in laboratory animals, such as mice and this imaging field has been a rapidly growing aimed at bridging... -
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- Higher Binding Affinity and In Vitro Potency of Reslizumab for Interleukin-5 Compared With Mepolizumab
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Liddament , Husten J, Estephan T, Laine D, Mabon D, Pukac L, Lyons J, Clarke AW, Doyle A
- KMID: 2431860
- Allergy Asthma Immunol Res.
- 2019 Mar;11(2):291-298.
- doi: 10.4168/aair.2019.11.2.291
Reslizumab and mepolizumab are recently approved monoclonal antibodies for the treatment of severe (uncontrolled) eosinophilic asthma. Both are effective in neutralizing the function of interleukin-5 (IL-5). This study is the... -
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- Higher Serum Calcium Levels Are Associated with Preclinical Peripheral Arterial Disease among the Apparently Healthy Individuals
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Kim HJ, Kim MR, Park JK, Lee YJ, Park B
- KMID: 2422106
- Korean J Fam Med.
- 2018 Sep;39(5):279-283.
- doi: 10.4082/kjfm.17.0035
BACKGROUND: Epidemiological studies suggest that serum calcium levels correlate with cardiovascular events. An ankle-brachial index (ABI) between 0.9 and 1.00 is a surrogate estimation of preclinical peripheral arterial disease (PAD).... -
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- Review of the UBC Porcine Model of Traumatic Spinal Cord Injury
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Kim KT, Streijger , Manouchehri N, So K, Shortt K, Okon EB, Tigchelaar S, Cripton P, Kwon BK
- KMID: 2420061
- J Korean Neurosurg Soc.
- 2018 Sep;61(5):539-547.
- doi: 10.3340/jkns.2017.0276
Traumatic spinal cord injury (SCI) research has recently focused on the use of rat and mouse models for in vivo SCI experiments. Such small rodent SCI models are invaluable for... -
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- The Generation and Application of Patient-Derived Xenograft Model for Cancer Research
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Jung J, Seol HS, Chang S
- KMID: 2403469
- Cancer Res Treat.
- 2018 Jan;50(1):1-10.
- doi: 10.4143/crt.2017.307
Establishing an appropriate preclinical model is crucial for translational cancer research. The most common way that has been adopted by far is grafting cancer cell lines, derived from patients. Although... -
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- Curriculum Development for Preclinical Medical Education at Yeungnam University
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Kim SY
- KMID: 2397972
- Korean Med Educ Rev.
- 2017 Oct;19(3):138-144.
After Yeungnam University's College of Medicine was established in 1979, the curriculum for a preclinical medical education course was developed and implemented. Several modifications have since been made to the... -
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- Subjective Cognitive Decline and Alzheimer's Disease Spectrum Disorder
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Hong YJ, Lee JH
- KMID: 2442825
- Dement Neurocogn Disord.
- 2017 Jun;16(2):40-47.
- doi: 10.12779/dnd.2017.16.2.40
Subjective cognitive decline (SCD) represents subjective complaints about cognitive decline in the absence of objective impairment in neuropsychological tests. Recently, growing evidence has suggested that SCD might be the first... -
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- Potential bias factors that affect the course evaluation of students in preclinical courses
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Chae SJ, Kim M, Chang KH, Chung YS
- KMID: 2413863
- Korean J Med Educ.
- 2017 Jun;29(2):73-80.
- doi: 10.3946/kjme.2017.54
PURPOSE: We aim to identify what potential bias factors affected students' overall course evaluation, and to observe what factors should be considered in the curriculum evaluation system of medical schools. METHODS:... -
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- Evaluation of Process and Satisfaction for Selective Courses in a Medical School
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Kim DH, Choi YH, Han SY, Shin JS, Lee S
- KMID: 2397963
- Korean Med Educ Rev.
- 2017 Jun;19(2):90-100.
The necessity of embracing selective courses in medical curriculum is increasing due to the expansion of medical knowledge and changes in the health care environment. In contrast to the abundant... -
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