Pediatr Gastroenterol Hepatol Nutr.  2020 Mar;23(2):163-173. 10.5223/pghn.2020.23.2.163.

Determinants of Circulating Soluble Leptin Receptor and Free Leptin Index in Indonesian Pre-Pubertal Obese Male Children: A Preliminary Cross-Sectional Study

Affiliations
  • 1Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. aryhendarto@yahoo.com
  • 2Department of Clinical Pharmacy, Padjajaran University, Bandung, Indonesia.

Abstract

PURPOSE
This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children.
METHODS
We conducted a preliminary cross-sectional study at three tertiary hospitals and one public primary school. Eighty obese male children without growth and developmental abnormalities aged 5-9 years were recruited. In these children, obesity was solely caused by excessive food intake, and not by acute illness, medications, endocrine abnormalities, or any syndrome. Body mass index (BMI), body fat mass, carbohydrate intake, fat intake, high density lipoprotein cholesterol level, low density lipoprotein cholesterol level, triglyceride level, and Homeostatic Model Assessment for Insulin Resistance are the potential determinants for leptin regulation, which is represented by CSLR level and FLI.
RESULTS
Carbohydrate was the main source of energy. BMI and body fat mass had negative weak correlation with CSLR and positive weak correlation with FLI. Furthermore, carbohydrate intake was found to be independently associated with CSLR based on the results of the multiple linear regression analysis. Following an increase in carbohydrate intake, CSLR level decreased progressively without any negative peak.
CONCLUSION
Leptin regulation in prepubertal obese male children is associated with body composition and dietary intake. Carbohydrate intake is useful for predicting CSLR. Lipid profiles and insulin resistance are not related to both CSLR and FLI. Treatment and prevention of leptin resistance in obese children should focus on reducing BMI, fat mass, and carbohydrate intake.

Keyword

Circulating soluble leptin receptor; Free leptin index; Body mass index; Body fat mass; Diet; Lipid; Insulin resistance

MeSH Terms

Adipose Tissue
Body Composition
Body Mass Index
Child*
Cholesterol, HDL
Cholesterol, LDL
Cross-Sectional Studies*
Diet
Eating
Growth and Development
Humans
Insulin Resistance
Leptin*
Linear Models
Male*
Obesity
Receptors, Leptin*
Tertiary Care Centers
Triglycerides
Cholesterol, HDL
Cholesterol, LDL
Leptin
Receptors, Leptin
Full Text Links
  • PGHN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error