J Korean Soc Laryngol Phoniatr Logoped.  2019 Dec;30(2):124-127. 10.22469/jkslp.2019.30.2.124.

A Case of Surgical Treatment of Intractable Vocal Fold Scar Using Basic Fibroblast Growth Factor and Collagen Scaffold

• Kang HT
• Kim HJ
• Park KN
• Lee SW

• KMID: 2470496
• DOI: http://doi.org/10.22469/jkslp.2019.30.2.124

Abstract

Vocal fold scarring is an intractable phonosurgical condition. The number of patients with vocal fold scars is increasing with the aging of society and with the increasing application of laryngeal microsurgery. Many methods are available to treat these, including voice therapy, stem cells, regenerative scaffolds, and growth factors. However, no standard treatment strategy has yet been established, and novel techniques are required. Basic fibroblast growth factor has been shown to be effective for the treatment of mild chronic vocal fold scarring. The combined use of basic fibroblast growth factor and regenerative scaffolds is currently under investigation. Here, we report a female patient in whom vocal fold scarring developed after two laryngeal microsurgeries. We performed laryngeal microsurgery to remove the scar tissue and used basic fibroblast growth factor and a collagen scaffold to promote healing. The patient's voice quality was greatly increased, and she was content with her voice after 2 years of follow-up. This is the first report of this methodology in Korea and is presented along with a review of the literature.

Keyword

Vocal fold; Scar; Regeneration

MeSH Terms

Aging
Cicatrix*
Collagen*
Female
Fibroblast Growth Factor 2*
Follow-Up Studies
Humans
Intercellular Signaling Peptides and Proteins
Korea
Microsurgery
Regeneration
Stem Cells
Vocal Cords*
Voice
Voice Quality
Collagen
Fibroblast Growth Factor 2
Intercellular Signaling Peptides and Proteins