J Dig Cancer Res.  2019 Dec;7(2):61-64. 10.0000/jdcr.2019.7.2.61.

Two Cases of Unresectable Pancreatic Cancer Treated with Neoadjuvant Chemotherapy and Surgical Resection

• Huh G
• Chun JW
• You MS
• Paik WH
• Lee SH
• Kim YT
• Ryu JK

• KMID: 2470444
• DOI: http://doi.org/10.0000/jdcr.2019.7.2.61

Abstract

We report two cases of patients with unresectable pancreatic cancer treated with neoadjuvant chemotherapy and surgical resection. In the first case, main mass was located at the neck of the pancreas, encasing superior mesenteric artery and peritoneal seeding was suspected. In the second case, main mass was located at the body of pancreas and superior mesenteric artery was encased. Both patients received FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. In both cases, tumor size decreased and vascular involvement regressed in response to chemotherapy. After subsequent chemoradiation therapy, both patients underwent surgical resection with negative resection margin. The pathological stages were ypT1cN0 and ypT1aN0, respectively. Both patients received postoperative adjuvant chemotherapy with 6 cycles of 5-FU/folinic acid and remained without evidence of disease for more than 6 months after the surgery.

Keyword

FOLFIRINOX; Neoadjuvant chemotherapy; Conversion surgery; Pancreatic cancer

MeSH Terms

Chemotherapy, Adjuvant
Drug Therapy*
Fluorouracil
Humans
Leucovorin
Mesenteric Artery, Superior
Neck
Pancreas
Pancreatic Neoplasms*
Fluorouracil
Leucovorin