Korean J Vet Res.  2019 Dec;59(4):219-222. 10.14405/kjvr.2019.59.4.219.

Nailbed malignant melanoma in three dogs

Abstract

Three 8-12-year-old male cocker spaniels presented with an appendicular mass accompanied by pain, inflammation, lameness, and loss of nail in the digits of the forelimb or hindlimb. A histological examination revealed dermal masses of the digit composed of numerous neoplastic cells with marked pleomorphism and high mitosis. The neoplastic cells showed a strong invasive tendency into the epidermis and adjacent bony tissues, such as distal phalanx. Immunohistochemistry of the neoplastic cells in three masses revealed positive reactions for Melan-A. These three dogs were diagnosed as nailbed malignant melanoma in the digit based on the history, clinical signs, and histopathologic features.


MeSH Terms

Animals
Dogs*
Epidermis
Forelimb
Hindlimb
Humans
Immunohistochemistry
Inflammation
Male
MART-1 Antigen
Melanoma*
Mitosis
MART-1 Antigen
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