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An atypical presentation of leiomyosarcoma causing extremity compartment syndrome of the crural region in a Dutch Warmblood mare: a case report

Giacchi A, Marcatili , Withers J, Knottenbelt D

A 12-year-old Warmblood mare was presented with an acute onset left hindlimb lameness associated with generalised soft tissue swelling of the entire limb and medial saphenous vein (MSV) thrombophlebitis. A...
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Exploratory, cognitive, and depressive-like behaviors in adult and pediatric mice exposed to controlled cortical impact

Lee SW, Jang MS, Jeong SH, Kim H

OBJECTIVE: Sequelae of behavioral impairments associated with human traumatic brain injury (TBI) include neurobehavioral problems. We compared exploratory, cognitive, and depressive-like behaviors in pediatric and adult male mice exposed to...
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Murine Model Study of a New Receptor-Targeted Tracer for Sentinel Lymph Node in Breast Cancer

Tian C, Sun X, Cong B, Qiu P, Wang Y

PURPOSE: Sentinel lymph node biopsy (SLNB), a critical staging and treatment step, has replaced axillary lymph node (LN) dissection as the standard staging procedure for early stage breast cancer patients...
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Nailbed malignant melanoma in three dogs

Three 8-12-year-old male cocker spaniels presented with an appendicular mass accompanied by pain, inflammation, lameness, and loss of nail in the digits of the forelimb or hindlimb. A histological examination...
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Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats

Lee S, Kim HB, Hwang ES, Kim ES, Kim SS, Jeon TD, Song MC, Lee JS, Chung MC, Maeng S, Park JH

Depression causes mental and physical changes which affect quality of life. It is estimated to become the second most prevalent disease, but despite its commonness, the pathophysiology of depression remains...
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Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice

Yoon Y, Park H, Kim S, Nguyen PT, Hyeon SJ, Chung S, Im H, Lee J, Lee SB, Ryu H

A recent study reveals that missense mutations of EWSR1 are associated with neurodegenerative disorders such as amyotrophic lateral sclerosis, but the function of wild-type (WT) EWSR1 in the central nervous...
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Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice

Moon EJ, Ko IG, Kim SE, Jin JJ, Hwang L, Kim CJ, An H, Lee BJ, Yi JW

PURPOSE: Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect. In this study, the action of dexmedetomidine on sleep...
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BubR1 Insufficiency Impairs Affective Behavior and Memory Function in Mice

Cho CH, Yang Z, Yoo KH, Oliveros A, Jang MH

PURPOSE: Although aging causes functional declines in cognition, the molecular mechanism underlying these declines remains largely unknown. Recently, the spindle checkpoint kinase budding uninhibited by benzimidazole-related 1 (BubR1) has emerged...
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Chronic Treatment with Combined Chemotherapeutic Agents Affects Hippocampal Micromorphometry and Function in Mice, Independently of Neuroinflammation

Kang S, Lee S, Kim J, Kim JC, Kim SH, Son Y, Shin T, Youn B, Kim JS, Wang H, Yang M, Moon C

Chemotherapeutic agents induce long-term side effects, including cognitive impairment and mood disorders, particularly in breast cancer survivors who have undergone chemotherapy. However, the precise mechanisms underpinning chemotherapy-induced hippocampal dysfunction remain...
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Gait analysis in clinically healthy small to toy breed dogs using a pressure plate

Hwang Y, Kim D, Kim G

Locomotion can be investigated using visual locomotion scoring or computer-assisted techniques such as force plates or pressure plates. Although visual locomotion scoring is inexpensive, it is subjective and depends on...
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Remote Ischemic Conditioning by Effluent Collected from a Novel Isolated Hindlimb Model Reduces Infarct Size in an Isolated Heart Model

Youn YJ, Yoo BS, Son JW, Lee JW, Ahn MS, Ahn SG, Kim JY, Lee SH, Yoon J, Eom YW, Oh JE, Choi SK

BACKGROUND AND OBJECTIVES: Experimental protocols for remote ischemic conditioning (RIC) utilize models in which a tourniquet is placed around the hindlimb or effluent is collected from an isolated heart. In...
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Rapid generation of OPC-like cells from human pluripotent stem cells for treating spinal cord injury

Kim DS, Jung SJ, Lee JS, Lim BY, Kim HA, Yoo JE, Kim DW, Leem JW

Remyelination via the transplantation of oligodendrocyte precursor cells (OPCs) has been considered as a strategy to improve the locomotor deficits caused by traumatic spinal cord injury (SCI). To date, enormous...
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Upregulation of miR-223 in the rat liver inhibits proliferation of hepatocytes under simulated microgravity

Chen Y, Xu J, Yang C, Zhang H, Wu F, Chen J, Li K, Wang H, Li Y, Li Y, Dai Z

Long-term spaceflight affects numerous organ systems in the body, including metabolic dysfunction. Recently, ample evidence has demonstrated that the liver is a vulnerable organ during spaceflight. However, the changes in...
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Engineered M13 Nanofiber Accelerates Ischemic Neovascularization by Enhancing Endothelial Progenitor Cells

Lee JH, Kim SW, Ji ST, Kim YJ, Jang WB, Oh JW, Kim J, Yoo SY, Beak SH, Kwon SM

Dysfunction or loss of blood vessel causes several ischemic diseases. Although endothelial progenitor cells (EPCs) are a promising source for cell-based therapy, ischemia-induced pathophysiological condition limits the recovery rate by...
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Comparative kinematic gait analysis in young and old Beagle dogs

Lorke M, Willen M, Lucas K, Beyerbach , Wefstaedt , Murua Escobar H, Nolte I

Age-related involution in dogs involves loss of muscle mass and changes in connective tissue and articular cartilage. The aim of this study was to examine whether an age-related influence on...
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Histopathological and Neurobehavioral Characterization in Adult Mice Exposed to Traumatic Brain Injury

Oh KY, Choi DW, Jang MS, Lee JH, Kim SC, Park JS, Lee SW, Kim H

PURPOSE: Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Severity of the initial insult is one of the most significant factors affecting outcome following TBI....
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Predictive Validity of Some Common Animal Models of Bipolar Disorder Using Lithium and Lamotrigine Therapy: An Attempt towards a Battery-Based Approach for the Evaluation of Mood Stabilizers

Kumar M, Tripathi C, Verma V, Padhy BM, Meshram GG, Abhilash B

OBJECTIVE: To determine the predictive validity of some of the commonly employed models of mania and depression using standard drugs i.e. lithium (70 mg/kg) and lamotrigine (5 mg/kg) in male...
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Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis

Ahn M, Kang S, Park C, Kim J, Jung K, Yang M, Kim SH, Moon C, Shin T

Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were...
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Directing Human Embryonic Stem Cells towards Functional Endothelial Cells Easily and without Purification

Gil CH, Ki BS, Seo J, Choi JJ, Kim H, Kim IG, Jung AR, Lee WY, Choi Y, Park K, Moon SH, Chung HM

Hemangioblasts or blood islands only arise in early development thereby the sources to obtain these bi-potential cells are limited. While previous studies have isolated both lineages in vitro through the...
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The Effect of Ischemic Preconditioning on the Expression of Serum Cytokines after 2 Hours Ischemia and Timely Reperfusion in the Hindlimb of Mice

Jin JH, Kim SJ, Seo Y, Kim S

The large volume of reactive oxygen species are generated during reperfusion after transient or post-procedural ischemia, which leads to cell injury. This ischemia-reperfusion (IR) injury may cause local and even...
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