Clin Exp Reprod Med.  2019 Mar;46(1):22-29. 10.5653/cerm.2019.46.1.22.

Effects of paternal age on human embryo development in in vitro fertilization with preimplantation genetic screening

• Kim MK
• Park JK
• Jeon Y
• Seok SH
• Chang EM
• Lee WS

• KMID: 2469603
• DOI: http://doi.org/10.5653/cerm.2019.46.1.22

Abstract

OBJECTIVE
As paternal age increases, the quality of sperm decreases due to increased DNA fragmentation and aneuploidy. Higher levels of structural chromosomal aberrations in the gametes ultimately decrease both the morphologic quality of embryos and the pregnancy rate. In this study, we investigated whether paternal age affected the euploidy rate.
METHODS
This study was performed using the medical records of patients who underwent in vitro fertilization (IVF) procedures with preimplantation genetic screening (PGS) from January 2016 to August 2017 at a single center. Based on their morphological grade, embryos were categorized as good- or poor-quality blastocysts. The effects of paternal age were elucidated by adjusting for maternal age.
RESULTS
Among the 571 total blastocysts, 219 euploid blastocysts were analyzed by PGS (38.4%). When the study population was divided into four groups according to both maternal and paternal age, significant differences were only noted between groups that differed by maternal age (group 1 vs. 3, p=0.031; group 2 vs. 4, p=0.027). Further analysis revealed no significant differences in the euploidy rate among the groups according to the morphological grade of the embryos.
CONCLUSION
Paternal age did not have a significant impact on euploidy rates when PGS was performed. An additional study with a larger sample size is needed to clarify the effects of advanced paternal age on IVF outcomes.

Keyword

Embryo quality; In vitro fertilization; Paternal age; Preimplantation genetic screening

MeSH Terms

Aneuploidy
Blastocyst
Chromosome Aberrations
DNA Fragmentation
Embryonic Development*
Embryonic Structures*
Female
Fertilization in Vitro*
Genetic Testing*
Germ Cells
Humans*
In Vitro Techniques*
Maternal Age
Medical Records
Paternal Age*
Pregnancy
Pregnancy Rate
Sample Size
Spermatozoa