Korean J Fertil Steril.  1998 Aug;25(2):135-140.

A Case of Successful Pregnancy in Patient with Recurrent Spontaneous Abortion by Preimplantation Genetic Diagnosis Following IVF-ET

• Jeong JS
• Yeon GS
• Chae HD
• Cheon YP
• Kim CH
• Kang BM
• Chang YS
• Mok JE

Abstract

It was reported that the etiologies of recurrent spontaneous abortion are immunologic factors, endocrinologic problems, anatomical abnormalities, genetic abnormalities, infection, and unexplained factors. Among those etiologic factors, genetic abnormalities occur in about 5% of the couples who experience recurrent spontaneous abortions, and most common parental chromosomal abnormality contributing to recurrent abortion is balanced translocation. The advent of in vitro fertilization (IVF), the development of skills associated with the handling of human embryo, and an explosion of knowledge in molecular biology have opened the possibility of early diagnosis of genetic disease in preimplantation embryos. Therefore preimplantation genetic diagnosis (PGD) is indicated for couples, infertile or not, at risk of transmitting a genetic disease. A case of successful pregnancy and term delivery by PGD using fluorescence in situ hybridization (FISH) technique in patient with recurrent spontaneous abortion due to balanced translocation is presented with brief review of literatures.

MeSH Terms

Abortion, Habitual
Abortion, Spontaneous*
Blastocyst
Chromosome Aberrations
Early Diagnosis
Embryonic Structures
Explosions
Family Characteristics
Female
Fertilization in Vitro
Fluorescence
Humans
Immunologic Factors
In Situ Hybridization
Molecular Biology
Parents
Pregnancy*
Preimplantation Diagnosis*
Prostaglandins D
Immunologic Factors
Prostaglandins D