- Recent Trends in Preimplantation Genetic Diagnosis (PGD)
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Kim JY, Kang IS
- KMID: 2272722
- Korean J Obstet Gynecol.
- 2005 Nov;48(11):2493-2509.
Preimplantation genetic diagnosis (PGD) provides practical option to prevent the termination of pregnancy and miscarriage in couples with high risk of genetic disease or recurrent spontaneous abortion. In balanced chromosomal... -
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- The first successful live birth following preimplantation genetic diagnosis using PCR for type 1 citrullinemia
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Cho JH, Kim CH, Lee KH, Jeon IK, Kim JM, Kang BM
- KMID: 1704434
- Obstet Gynecol Sci.
- 2014 May;57(3):244-247.
- doi: 10.5468/ogs.2014.57.3.244
Type 1 citrullinemia (CTLN1) is an autosomal recessive inherited metabolic disorder caused by anargininosuccinicnate synthetase deficiency. The patient was a 38-year-old Korean woman who is a carrier for CTLN1 and... -
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- A Case of Successful Pregnancy in Patient with Recurrent Spontaneous Abortion by Preimplantation Genetic Diagnosis Following IVF-ET
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Jeong JS, Yeon GS, Chae HD, Cheon YP, Kim CH, Kang BM, Chang YS, Mok JE
- KMID: 2304573
- Korean J Fertil Steril.
- 1998 Aug;25(2):135-140.
It was reported that the etiologies of recurrent spontaneous abortion are immunologic factors, endocrinologic problems, anatomical abnormalities, genetic abnormalities, infection, and unexplained factors. Among those etiologic factors, genetic abnormalities occur... -
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- The Ethical and Legal Considerations on Preimplantation Genetic Diagnosis and Prenatal Diagnosis
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Kim JH
- KMID: 2272988
- Korean J Obstet Gynecol.
- 2006 Dec;49(12):2497-2505.
OBJECTIVE: After 'Bioethics & biosafety act' has been enacted since 2005, Preimplantation genetic diagnosis (PGD) for embryo and Prenatal diagnosis (PD) for fetus are regulated by this law. This article... -
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- Clinical application of preimplantation genetic diagnosis (PGD) using fluorescence in-situ hybridization to balanced reciprocal or Robertsonian translocation carriers in human IVF-ET program
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Jun JH, Song GJ, Kim JW, Park SY, Kim KH, Choi BC, Koong MK, Kang IS, Lim CK, Han MH
- KMID: 2262031
- Korean J Obstet Gynecol.
- 2000 Jul;43(7):1147-1153.
OBJECTIVE: This study was performed to evaluate the efficiency of preimplantation genetic diagnosis (PGD) using fluorescence in-situ hybridization (FISH) in Robertsonian or balanced reciprocal translocation carriers in human IVF-ET programm. METHOD: FISH... -
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- Preimplantation Genetic Diagnosis for Single Gene Disorders
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Lee HS, Kim MJ, Kang IS
- KMID: 1473817
- J Genet Med.
- 2009 Dec;6(2):131-145.
Preimplantation genetic diagnosis (PGD) has become an assisted reproductive technique for couples who are at risk that enables them to have unaffected baby without facing the risk of pregnancy termination... -
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- Application of Hot Start PCR Method in PCR-based Preimplantation Genetic Diagnosis
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Kim SA, Kang MJ, Kim HS, Oh SK, Ku SY, Choi YM, Jun JK, Moon SY
- KMID: 2055563
- J Genet Med.
- 2012 Jun;9(1):11-16.
- doi: 10.5734/JGM.2012.9.1.11
PURPOSE: To determine a method to improve the efficacy and accuracy of preimplantation genetic diagnosis (PGD) - polymerase chain reaction (PCR), we compared hot start PCR and conventional multiplex nested... -
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- Birth of a healthy baby after preimplantation genetic diagnosis in a carrier of mucopolysaccharidosis type II: The first case in Korea
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Ko DS, Lee SH, Park CW, Lim CK
- KMID: 2469598
- Clin Exp Reprod Med.
- 2019 Dec;46(4):206-210.
- doi: 10.5653/cerm.2019.00094
Mucopolysaccharidosis type II (MPS II) is a rare X-linked recessive lysosomal storage disease caused by mutation of the iduronate-2-sulfatase gene. The mutation results in iduronate-2-sulfatase deficiency, which causes the progressive... -
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- Preimplantation genetic diagnosis
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Kim JY, Lee HS, Kang IS
- KMID: 2195126
- J Korean Med Assoc.
- 2015 Nov;58(11):979-988.
- doi: 10.5124/jkma.2015.58.11.979
Preimplantation genetic diagnosis (PGD) is a technique to examine genetic disease or chromosome abnormalities in single cell biopsied from embryos before implantation to uterus. It allows achieving normal pregnancy by... -
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- Outcomes of preimplantation genetic diagnosis using either zona drilling with acidified Tyrode's solution or partial zona dissection
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Kim HJ, Kim CH, Lee SM, Choe SA, Lee JY, Jee BC, Hwang D, Kim KC
- KMID: 2167510
- Clin Exp Reprod Med.
- 2012 Sep;39(3):118-124.
- doi: 10.5653/cerm.2012.39.3.118
OBJECTIVE: To review the outcomes of preimplantation genetic diagnosis (PGD) using zona drilling with acid Tyrode's solution (chemical zona pellucida drilling, chemical ZD) and those of partial zona dissection (PZD). METHODS:... -
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- Does blastomere biopsy in preimplantation genetic diagnosis affect early serum beta-hCG levels?
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Cho YJ, Kim JY, Song IO, Lee HS, Lim CK, Koong MK, Kang IS
- KMID: 1805486
- Clin Exp Reprod Med.
- 2011 Mar;38(1):31-36.
- doi: 10.5653/cerm.2011.38.1.31
OBJECTIVE: To determine whether the serum beta-human chorionic gonadotropin (hCG) profile following preimplantation genetic diagnosis (PGD) is lower than that of intracytoplasmic sperm injection (ICSI) cycles. METHODS: A total of 129... -
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- Preimplantation genetic diagnosis for Charcot-Marie-Tooth disease
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Lee HS, Kim MJ, Ko DS, Jeon EJ, Kim JY, Kang IS
- KMID: 2167494
- Clin Exp Reprod Med.
- 2013 Dec;40(4):163-168.
- doi: 10.5653/cerm.2013.40.4.163
OBJECTIVE: Preimplantation genetic diagnosis (PGD) is an assisted reproductive technique for couples carrying genetic risks. Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuropathy, with a prevalence rate of 1/2,500.... -
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- Detection of Y Mosaicism in Blood and Gonad of Patients with Gonadal Dysgenesis
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Kim JY, Lee SJ, Park KH, Kim JY, Bai SW, Lee BS, Kim SK, Kim IK, Cho DJ, Song CH, Kim JW, Lee HJ
- KMID: 1891294
- Korean J Fertil Steril.
- 1999 Dec;26(3):457-466.
OBJECTIVE: The presence of Y Chromosome in patients with gonadal dysgenesis is related to the risk of gonadoblastoma. Since the patients with abnormal sexual differentiation may have cryptic Y mosaicism,... -
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- Age or Basal Serum FSH Levels; Which One is Better for Prediction of IVF Outcomes in Patients with Decreased Ovarian Reserve?
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Yu Y, Kim MJ, Cho YJ, Yeon MJ, Ahn YS, Cha SH, Kim HO, Park CW, Kim JY, Song IO, Koong MK, Kang IS, Jun JY, Yang KM
- KMID: 1986939
- Korean J Reprod Med.
- 2007 Sep;34(3):189-196.
OBJECTIVES: The purpose of this study is to investigate the clinical significance of age and basal serum FSH in predicting the outcomes of in vitro fertilization (IVF) in patients with... -
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- Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center
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Won SY, Kim H, Lee WS, Kim JW, Shim SH
- KMID: 2420157
- Obstet Gynecol Sci.
- 2018 Jan;61(1):95-101.
- doi: 10.5468/ogs.2018.61.1.95
OBJECTIVE: Indications for preimplantation genetic diagnosis (PGD)/preimplantation genetic screening (PGS) cycles and clinical outcomes were evaluated at CHA Gangnam Medical Center. METHODS: This is retrospective cohort study. All patients (n=336) who... -
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- Optimized Methods of Preimplantation Genetic Diagnosis for Trinucleotide Repeat Diseases of Huntington's Disease, Spinocerebellar Ataxia 3 and Fragile X Syndrome
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Kim MJ, Lee HS, Lim CK, Cho JW, Kim JY, Koong MK, Song IO, Kang IS, Jun JH
- KMID: 1986938
- Korean J Reprod Med.
- 2007 Sep;34(3):179-188.
OBJECTIVES: Many neurological diseases are known to be caused by expansion of trinucleotide repeats (TNRs). It is hard to diagnose the alteration of TNRs with single cell level for preimplantation... -
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- Successful birth with preimplantation genetic diagnosis using single-cell allele-specific PCR and sequencing in a woman with hypochondroplasia due to FGFR3 mutation (c.1620C>A, p.N540K)
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Park KE, Kim SA, Kang MJ, Kim HS, Cho SI, Yoo KW, Kim SY, Lee HJ, Oh SK, Seong MW, Ku SY, Jun JK, Park SS, Choi YM, Moon SY
- KMID: 1430083
- Clin Exp Reprod Med.
- 2013 Mar;40(1):42-46.
- doi: 10.5653/cerm.2013.40.1.42
Hypochondroplasia (HCH) is an autosomal dominant inherited skeletal dysplasia, usually caused by a heterozygous mutation in the fibroblast growth factor receptor 3 gene (FGFR3). A 27-year-old HCH woman with a... -
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- Developmental competence and Effects of Coculture after Crypreservation of Blastomere-Biopsied Mouse Embryos as a Preclinical Model for Preimplantation Genetic Diagnosis
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Kim JG, Lee JY, Kim SH, Jee BC, Suh CS, Choi YM, Moon SY
- KMID: 2235713
- Korean J Fertil Steril.
- 2000 Mar;27(1):47-58.
OBJECTIVE: The effects of cryopreservation with or without coculture on the in vitro development of blastomere-biopsied 8-cell mouse embryos were investigated. This experimental study was originally designed for the setup... -
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- Improvement of Pregnancy Rate in Preimplantation Genetic Diagnosis with FISH Procedure by the Laboratory Optimization and Experiences
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Lim CK, Min DM, Lee HS, Byun HK, Park SY, Ryu HM, Kim JY, Koong MK, Kang IS, Jun JH
- KMID: 1891198
- Korean J Fertil Steril.
- 2004 Mar;31(1):29-39.
OBJECTIVES: This study was performed to evaluate the laboratory system for successful PGD using fluorescence in situ hybridization (FISH) and the clinical outcome of PGD cycles in five years experiences. METHODS:... -
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- Efficacy of Duplex-nested PCR and Fluorescent PCR in the Preimplantation Genetic Diagnosis for Duchenne Muscular Dystrophy
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Lee HS, Choi HW, Lim CK, Park SY, Kim JY, Koong MK, Jun JH, Kang IS
- KMID: 1772283
- Korean J Fertil Steril.
- 2005 Mar;32(1):17-26.
OBJECTIVE: Preimplantation genetic diagnosis (PGD) is reserved for couples with a risk of transmitting a serious and incurable disease, and hence avoids the undesirable therapeutic abortion. In this study, we... -
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