Clin Exp Reprod Med.  2011 Mar;38(1):31-36. 10.5653/cerm.2011.38.1.31.

Does blastomere biopsy in preimplantation genetic diagnosis affect early serum beta-hCG levels?

• Cho YJ
• Kim JY
• Song IO
• Lee HS
• Lim CK
• Koong MK
• Kang IS

• KMID: 1805486
• DOI: http://doi.org/10.5653/cerm.2011.38.1.31

Abstract

OBJECTIVE
To determine whether the serum beta-human chorionic gonadotropin (hCG) profile following preimplantation genetic diagnosis (PGD) is lower than that of intracytoplasmic sperm injection (ICSI) cycles.
METHODS
A total of 129 PGD cycles and 1,161 age-matched ICSI cycles, which resulted in pregnancy (serum beta-hCG> or =5 mIU/mL) on post-ovulation day (POD) 12 were included. We compared the mean serum beta-hCG levels on POD 12, 14, 21, and 28, doubling time of serum hCG, and created a cut-off value for predicting a singleton pregnancy in each group.
RESULTS
The mean serum beta-hCG concentration of the PGD group was significantly lower than that of the control group on POD 12, 14, and 21. The doubling time of serum beta-hCG at each time interval showed no significant difference. The cut-off-value of serum beta-hCG for predicting a single viable pregnancy was 32.5 mIU/mL on POD 12 and 113.5 mIU/mL on POD 14 for the PGD group, which was lower than that for the control group.
CONCLUSION
Blastomere biopsy may decrease the beta-hCG-producing activity of the trophoblasts, especially in early pregnancy. Setting a lower cut-off value of serum beta-hCG for predicting pregnancy outcomes in PGD may be needed.

Keyword

Preimplantation Genetic Diagnosis; Human Chorionic Gonadotropin; Blastomeres; Biopsy; Pregnancy Outcome; Human

MeSH Terms

Biopsy
Blastomeres
Chorionic Gonadotropin
Female
Humans
Pregnancy
Pregnancy Outcome
Preimplantation Diagnosis
Prostaglandins D
Sperm Injections, Intracytoplasmic
Trophoblasts
Chorionic Gonadotropin
Prostaglandins D