Nucl Med Mol Imaging.
2019 Dec;53(6):406-413. 10.1007/s13139-019-00617-7.
Comparative Analysis of Lung Perfusion Scan and SPECT/CT for the Evaluation of Functional Lung Capacity
- Affiliations
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- 1Department of Nuclear Medicine, National Cancer Center, Goyang, Republic of Korea. skkim@ncc.re.kr
- 2Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
- 3Department of Thoracic Surgery, National Cancer Center, Goyang, Republic of Korea.
- KMID: 2469584
- DOI: http://doi.org/10.1007/s13139-019-00617-7
Abstract
- PURPOSE
This study aimed to compare lung perfusion scan with single photon emission computed tomography/computed tomography (SPECT/CT) for the evaluation of lung function and to elucidate the most appropriate modality for the prediction of postoperative lung function in patients with lung cancer.
METHODS
A total of 181 patients underwent Tc-99m macroaggregated albumin lung perfusion scan and SPECT/CT to examine the ratio of diseased lung and diseased lobe. Forty-one patients with lung cancer underwent both preoperative and postoperative pulmonary function tests within 1 month to predict postoperative pulmonary function. Predicted postoperative forced expiratory volume in 1 s (ppoFEVâ‚) was calculated by the % radioactivity of lung perfusion scan and SPECT, and the % volume of the residual lung, assessed on CT.
RESULTS
The ratios of diseased lung as seen on lung perfusion scan and SPECT showed significant correlation, but neither modality correlated with CT. The ratios of the diseased lung and diseased lobe based on CT were higher than the ratios based on either perfusion scan or SPECT, because CT overestimated the function of the diseased area. The lobar ratio of both upper lobes was lower based on the perfusion scan than on SPECT but was higher for both lower lobes. Actual postoperative FEVâ‚ showed significant correlation with ppoFEVâ‚ based on lung perfusion SPECT and perfusion scan.
CONCLUSIONS
We suggest SPECT/CT as the primary modality of choice for the assessment of the ratio of diseased lung area. Both perfusion scan and SPECT/CT can be used for the prediction of postoperative lung function.
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