Ewha Med J.  2020 Jan;43(1):1-11. 10.12771/emj.2020.43.1.1.

Intelectin-1 and Endocrinological Parameters in Women with Polycystic Ovary Syndrome: Effect of Insulin Resistance

Affiliations
  • 1Department of Chemistry, College of Science, University of Basra, Basra, Iraq. adnan.Jassim@uobasrah.edu.iq

Abstract


OBJECTIVES
We aimed to evaluate the effect of insulin resistance (IR) on serum Intelectin-1 and endocrinological hormones levels in obese and non-obese women with and without polycystic ovary syndrome (PCOS) in Basrah, Iraq.
METHODS
From 124 women volunteers, 60 patients with primary and 64 patients with secondary, while 56 normal ovulatory women were taken as controls. Their fasting insulin hormone, intelectin-1, anti-Mullerian hormone, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), estradiol (E2) and testosterones (T) were determined by ELISA methods. BMI, glucose and quantitative insulin sensitivity check index as well as IR was determined by the homeostasis model assessment.
RESULTS
A significant changes (P<0.05) were seen in the level of homeostasis model assessment-IR, E2 and T. Levels of anti-Mullerian hormone, LH, LH/FSH ratio and prolactin were significantly (P<0.01) increased and level of intelectin-1 and E2/T ratio were significantly (P<0.01) decreased, while quantitative insulin sensitivity check index level was not significantly different (P>0.05) between the patients (1┬░PCOS and 2┬░PCOS) and control groups. On the other hand, our data reported that FSH level was significantly (P<0.05) lower in obese and higher in non-obese patients with PCOS as compared to control group.
CONCLUSION
Levels of intelectin-1 and endocrinological hormones have significantly associated with body mass index, IR and physical activity in patients and normal groups and the strategies that can modulate levels of these parameters would improve metabolic disarrangements in women with PCOS.

Keyword

Intelectin-1; Body mass index; Insulin resistance; Gonadal steroid hormones; Polycystic ovary syndrome

MeSH Terms

Anti-Mullerian Hormone
Body Mass Index
Enzyme-Linked Immunosorbent Assay
Estradiol
Fasting
Female
Follicle Stimulating Hormone
Glucose
Gonadal Steroid Hormones
Hand
Homeostasis
Humans
Insulin Resistance*
Insulin*
Iraq
Luteinizing Hormone
Motor Activity
Polycystic Ovary Syndrome*
Prolactin
Volunteers
Anti-Mullerian Hormone
Estradiol
Follicle Stimulating Hormone
Glucose
Gonadal Steroid Hormones
Insulin
Luteinizing Hormone
Prolactin
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