Int Neurourol J.  2019 Nov;23(Suppl 2):S82-S92. 10.5213/inj.1938214.107.

Exercise and Neuroinflammation in Health and Disease

• Seo DY
• Heo JW
• Ko JR
• Kwak HB

• KMID: 2467316
• DOI: http://doi.org/10.5213/inj.1938214.107

Abstract

Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces microglia activation, mitochondrial dysfunction, the production of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), pro-inflammatory cytokines, and reactive oxygen species. Exercise, which plays an important role in maintaining and improving brain health, might be a highly effective intervention for preventing neuroinflammation-related diseases. Thus, since exercise can improve the neuroimmune response, we hypothesized that exercise would attenuate neuroinflammation-related diseases. In this review, we will highlight (1) the biological mechanisms that underlie AD, PD, ALS, and MS, including the neuroinflammation pathways associated with microglia activation, NF-κB, pro-inflammatory cytokines, mitochondrial dysfunction, and reactive oxygen species, and (2) the role of exercise in neuroinflammation-related neurodegenerative diseases.

Keyword

Exercise; Neuroinflammation; Health; Disease

MeSH Terms

Alzheimer Disease
Amyotrophic Lateral Sclerosis
B-Lymphocytes
Brain
Brain Diseases
Cytokines
Microglia
Multiple Sclerosis
Neurodegenerative Diseases
Parkinson Disease
Reactive Oxygen Species
Cytokines
Reactive Oxygen Species