Korean J Biol Psychiatry.  2016 Feb;23(1):12-17. 10.0000/kjbp.2016.23.1.12.

Neuroinflammation and Psychiatric Illness

• Song HR
• Lee HY
• Shim SH
• Kwon YJ

• KMID: 2251106
• DOI: http://doi.org/10.0000/kjbp.2016.23.1.12

Abstract

Neuroinflammation is one of important allostatic loads contributory to the various psychiatric illness. It is mediated mainly by glial cells, which produce both proinflammatory and antiinflammatory cytokines, and the balance of them determines the inflammatory process in the central nervous system. S100 calcium-binding protein B, which is used as an inflammatory marker is also released by glial cells. In the molecular level, oxidative stress contributes to the neuroinflammation. Their disturbances have been revealed in the psychiatric illness and related with the dysregulation of the glutamatergic and monoaminergic systems. There is a possibility to use them as disease markers. The approach for inflammation using antiinflammatory drugs and antioxidants could be connected to the development of disease-modifying treatments. Also, a searching examination about specific subtypes who are vulnerable to inflammation in the patients is required to confirm their efficacy clearly.

Keyword

Neuroinflammation; Cytokine; S100B; Oxidative stress

MeSH Terms

Allostasis
Antioxidants
Central Nervous System
Cytokines
Humans
Inflammation
Neuroglia
Oxidative Stress
Antioxidants
Cytokines