Lab Med Online.  2020 Jan;10(1):1-9. 10.3343/lmo.2020.10.1.1.

Recommendations for the Use of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory: Part I. Implementation and Management

  • 1Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, National University Bundang Hospital, Seongnam, Korea.
  • 2Department of Laboratory Medicine, Pusan National University Hospital, Busan, Korea.
  • 3Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea.
  • 4Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea.
  • 5Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • 6Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 7Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.


Many types of assays involving mass spectrometry have been developed and applied in clinics. However, mass spectrometry has not been widely implemented yet relative to other measurement methods, including biochemical assays, immunoassays, and molecular diagnostics. Despite its strong advantage as an analytical method, many laboratory physicians and clinical laboratories are unwilling to introduce it. Fundamental elements, such as instruments, reagents, facilities, skilled human resources are required to implement mass spectrometry. This review contains considerations for the introduction of liquid chromatography-mass spectrometry to support the clinical laboratories interested in or planning to implement mass spectrometry.


Liquid chromatography-mass spectrometry (LC-MS); Clinical laboratory; Mass spectrometric assay

MeSH Terms

Indicators and Reagents
Mass Spectrometry
Pathology, Molecular
Spectrum Analysis*
Indicators and Reagents
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