Lab Med Online.  2020 Jan;10(1):1-9. 10.3343/lmo.2020.10.1.1.

Recommendations for the Use of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory: Part I. Implementation and Management

• Lee K
• Moon SY
• Kim S
• Choi HJ
• Lee SG
• Park HD
• Lee SY
• Song SH
• Clinical Mass Spectrometry Research Committee of the Korean Society of Clinical Chemistry

• KMID: 2466760
• DOI: http://doi.org/10.3343/lmo.2020.10.1.1

Abstract

Many types of assays involving mass spectrometry have been developed and applied in clinics. However, mass spectrometry has not been widely implemented yet relative to other measurement methods, including biochemical assays, immunoassays, and molecular diagnostics. Despite its strong advantage as an analytical method, many laboratory physicians and clinical laboratories are unwilling to introduce it. Fundamental elements, such as instruments, reagents, facilities, skilled human resources are required to implement mass spectrometry. This review contains considerations for the introduction of liquid chromatography-mass spectrometry to support the clinical laboratories interested in or planning to implement mass spectrometry.

Keyword

Liquid chromatography-mass spectrometry (LC-MS); Clinical laboratory; Mass spectrometric assay

MeSH Terms

Humans
Immunoassay
Indicators and Reagents
Mass Spectrometry
Methods
Pathology, Molecular
Spectrum Analysis*
Indicators and Reagents

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