Dement Neurocogn Disord.  2019 Dec;18(4):130-137. 10.12779/dnd.2019.18.4.130.

The Effect of Clinical Characteristics and Subtypes on Amyloid Positivity in Patients with Amnestic Mild Cognitive Impairment

• Kim JY
• Lim JH
• Jeong YJ
• Kang DY
• Park KW

• KMID: 2466756
• DOI: http://doi.org/10.12779/dnd.2019.18.4.130

Abstract

BACKGROUND AND PURPOSE
Mild cognitive impairment (MCI) is a prodromal stage of dementia. Amyloid deposits in positron-emission tomography (PET) imaging of MCI patients imply a higher risk for advancing to dementia, with rates of 10%-15% yearly. The purpose of this study was to investigate the clinical characteristics of subgroups of amnestic MCI (aMCI) that may have a higher impact on amyloid positivity.
METHODS
We recruited 136 aMCI patients. All patients underwent a 20-minute F-18 florbetaben or flutemetamol PET scan. We classified amyloid PET images as positive or negative according to a semi-quantitative method. We evaluated the amyloid positivity of subgroups of aMCI (early vs. late type, single vs. multiple amnestic type, verbal vs. verbal, and visual amnestic type), and compared baseline clinical characteristics including key risk factors, apolipoprotein E4 (apoE4) genotype, and neuropsychological assessments with amyloid positivity in aMCI.
RESULTS
The amyloid positivity in total aMCI was 41%. The positivity rate according to subgroup of aMCI were as follow: Late aMCI (49%) vs. early aMCI (33%) (p=0.13), multiple aMCI (40%) vs. single aMCI (38%) (p=0.51), and verbal and visual aMCI (59%) vs. verbal aMCI (35%) (p=0.01), respectively. The mean age and the frequency of apoE4 allele of the amyloid-positive group was higher than that of the amyloid-negative group in aMCI (p< 0.01).
CONCLUSIONS
We found that the amyloid positivity was related to patterns of clinical subtypes, characteristics, and risk factors in patients with aMCI.

Keyword

Mild Cognitive Impairment; Amyloid; Positron Emission Tomography

MeSH Terms

Alleles
Amyloid*
Apolipoprotein E4
Dementia
Genotype
Humans
Methods
Mild Cognitive Impairment*
Plaque, Amyloid
Positron-Emission Tomography
Prodromal Symptoms
Risk Factors
Amyloid
Apolipoprotein E4

Figure

• 

  Fig. 1 Results of amyloid positivity rate according to aMCI subtype. aMCI: amnestic mild cognitive impairment, Both: verbal and visual.

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