Nucl Med Mol Imaging.  2019 Oct;53(5):334-339. 10.1007/s13139-019-00609-7.

Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET

• Jeong J
• Jeong YJ
• Park KW
• Kang DY

• KMID: 2465869
• DOI: http://doi.org/10.1007/s13139-019-00609-7

Abstract

PURPOSE
To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB).
METHODS
We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50??0 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex.
RESULTS
The distribution of amyloid beta for each brain region revealed no age-related trends (p > 0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 ± 0.18. The right parietal lobe showed the highest SUVR value (1.46 ± 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 ± 0.25).
CONCLUSIONS
We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer's disease.

Keyword

Alzheimer's disease; F-18 florbetaben; Healthy; SUVR

MeSH Terms

Adult*
Aged
Alzheimer Disease
Amyloid*
Brain
Cerebellar Cortex
Diagnosis
Frontal Lobe
Humans
Parietal Lobe
Plaque, Amyloid
Positron-Emission Tomography
Prospective Studies
Reference Values
Amyloid