Clin Endosc.  2019 Sep;52(5):472-478. 10.5946/ce.2018.152.

Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection

• Jeong E
• Yoo IK
• Cakir OO
• Kim HK
• Kim WH
• Hong SP
• Cho JY

• KMID: 2464669
• DOI: http://doi.org/10.5946/ce.2018.152

Abstract

BACKGROUND/AIMS
Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was to evaluate the clinical efficacy and safety of local PRP injections after endoscopic submucosal dissection (ESD).
METHODS
Patients were non-randomly divided into the following two groups: (1) control group in which patients were administered only an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and a topical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28 days after endoscopic surgery).
RESULTS
We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% in the control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study group compared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were no serious complications in either group.
CONCLUSIONS
The local injection of PRP is a safe and effective procedure for ulcer healing after ESD.

Keyword

Endoscopic submucosal dissection; Platelet-rich plasma; Ulcer healing

MeSH Terms

Humans
Platelet-Rich Plasma*
Proton Pumps
Treatment Outcome
Ulcer*
Wound Healing
Proton Pumps

Figure

• 

  Fig. 1. Platelet-rich plasma (PRP) preparation.

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  Fig. 2. Method of platelet-rich plasma (PRP) injection. ESD, endoscopic submucosal dissection.

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  Fig. 3. Change of ulcer (endoscopic finding) 24 hours after endoscopic submucosal dissection.(A) Study (platelet-rich plasma) group 24 hours after endoscopic submucosal dissection (ESD). (B) Study (platelet-rich plasma) group 28 days after ESD. (C) Control group 24 hours after ESD. (D) Control group 28 days after ESD.

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