J Korean Burn Soc.
2011 Jun;14(1):1-5.
Effect of Platelet-rich Plasma on Burn Wounds according to Time of Application: An Experimental Study on Rats
- Affiliations
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- 1Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea. psthchoi@snu.ac.kr
Abstract
- PURPOSE
One of the main subjects that burn researches are focused on is saving the zone of stasis. Platelet-rich plasma stimulates angiogenesis, promoting vascular in-growth and fibroblast proliferation. In addition, platelet-rich plasma functions as haemostatic agent by forming a fibrin clot. Also application of platelet-rich plasma enhances wound-healing in both soft and hard tissue. In this study, the effect of the platelet-rich plasma on the zone of stasis was evaluated.
METHODS
Sixteen F344/N Slc Inbred Rats were used and randomly separated into four groups. Autologous platelet-rich plasma was harvested and applied to each group of burn wound model at different times.
RESULTS
After 20 days, burn wounds of each group healed well. However, healing speed was different in each group. The group to which platelet-rich plasma was applied 4 hours after burn injury had healed about 1.38 times faster than control group.
CONCLUSION
The results showed that platelet-rich plasma is an effective substance for saving the zone of stasis. It is not only well-known, but also easy to harvest and easy to use. Thus autologous platelet-rich plasma could be a valuable addition to existing burn treatment methods.