J Korean Med Sci.  2019 Nov;34(45):e291. 10.3346/jkms.2019.34.e291.

Recent Trends in Demographics, Surgery, and Prognosis of Patients with Surgically Resected Lung Cancer in a Single Institution from Korea

• Yun JK
• Lee HP
• Lee GD
• Kim HR
• Kim YH
• Kim DK
• Park SI
• Choi S

• KMID: 2463685
• DOI: http://doi.org/10.3346/jkms.2019.34.e291

Abstract

BACKGROUND
Over the past few decades, demographics information has changed significantly in patients with surgically resected lung cancer. Herein, we evaluated the recent trends in demographics, surgery, and prognosis of lung cancer surgery in Korea.
METHODS
Patients with surgically resected primary lung cancer from 2002 to 2016 were retrospectively analyzed. Multivariable Cox regression analysis was conducted to identify prognostic factors for overall survival. The annual percent change (APC) and statistical significance were calculated using the Joinpoint software.
RESULTS
A total of 7,495 patients were enrolled. Over the study period, the number of lung cancer surgeries continued to increase (P < 0.05). The proportion of women to total subjects has also increased (P < 0.05). The proportion of elderly patients (≥ 70 years) as well as those with tumors measuring 1-2 cm and 2-3 cm significantly increased in both genders (all P < 0.05). The proportion of patients with adenocarcinoma, video-assisted thoracic surgery, sublobar resection, and pathological stage I significantly increased (P < 0.05). The 5-year overall survival rate of lung cancer surgery increased from 61.1% in 2002-2006 to 72.1% in 2012-2016 (P < 0.001). The operative period was a significant prognostic factor in multivariable Cox analysis (P < 0.001).
CONCLUSION
The mean age of patients with lung cancer surgery increased gradually, whereas tumor size reduced. Prognosis of lung cancer surgery improved with recent increases in the frequency of adenocarcinoma, video-assisted thoracic surgery, sublobar resection, and pathological stage I. The operation period itself was also an independent prognostic factor for overall survival.

Keyword

Time Trend; Demography; Surgical Resection; Surgical Outcome; Non-Small Cell Lung Cancer; Republic of Korea

MeSH Terms

Adenocarcinoma
Aged
Carcinoma, Non-Small-Cell Lung
Demography*
Female
Humans
Korea*
Lung Neoplasms*
Lung*
Prognosis*
Republic of Korea
Retrospective Studies
Survival Rate
Thoracic Surgery, Video-Assisted