J Korean Med Sci.  2012 Dec;27(12):1486-1490. 10.3346/jkms.2012.27.12.1486.

Changes in the Demographics and Prognoses of Patients with Resected Non-Small Cell Lung Cancer: A 20-Year Experience at a Single Institution in Korea

• Lee JG
• Lee CY
• Bae MK
• Byun CS
• Kim DJ
• Chung KY

• KMID: 2157971
• DOI: http://doi.org/10.3346/jkms.2012.27.12.1486

Abstract

The demographics and prognosis of non-small cell lung cancer patients have changed during the last few decades. We conducted this study to assess the change in demographics and prognosis in resected non-small cell lung cancer patients during a 20-yr single-institution study in Korea. We retrospectively reviewed the medical records of 2,076 non-small cell lung cancer patients who underwent pulmonary resection between 1990 and 2009. Their clinical characteristics and survival were analyzed over a five-year period. With time, the proportions of female, adenocarcinoma, stage IA, and lobectomy patients increased, whereas the proportions of male, squamous cell carcinoma, stage IIIA, and pneumonectomy patients decreased. These demographic changes caused improved prognosis. The five-year survival rate of all patients was 53.9%. The five-year survival rate increased from 31.9% in 1990-1994, to 43.6% in 1995-1999, 51.3% in 2000-2004, and 69.7% in 2005-2009 (P < 0.001). In conclusion, among patients with resected non-small cell lung cancer, the proportions of female, adenocarcinoma, stage IA, and lobectomy patients have increased, and the five-year survival rate has gradually improved during the last 20 yr in Korea.

Keyword

Demography; Prognosis; Change; Carcinoma; Non-Small Cell Lung Cancer

MeSH Terms

Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung/*diagnosis/mortality/surgery
Child
Demography
Female
Humans
Lung Neoplasms/*diagnosis/mortality/surgery
Male
Middle Aged
Neoplasm Staging
Prognosis
Republic of Korea
Retrospective Studies
Survival Rate
Young Adult

Figure

• 

  Fig. 1 Number of NSCLC patients with resection, adenocarcinoma and stage I according to time. The proportion of patients with pathologic stage I disease and adenocarcinoma increased from 16.6% (5/30) and 33.3% (10/30), respectively, in 1990 to 58.2% (131/225) and 64.0% (144/225), respectively, in 2009 (NSCLC: non-small cell lung cancer).

• 

  Fig. 2 Postoperative overall survival curves for patients according to time period. The five-year survival rate improved over the 20-yr study period and there were significant differences among the groups (P < 0.001) (5YSR: Five-year survival rate).

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