Osteoporos Sarcopenia.  2019 Sep;5(3):82-84. 10.1016/j.afos.2019.08.001.

Early reduced bone formation following burn injury in rats is not inversely related to marrow adiposity

Affiliations
  • 1Departments of Surgery and Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch and Shriners Burns Hospital, Galveston TX and Maine Medical Research Institute, Scarborough, ME, USA. gordonklein@ymail.com

Abstract


OBJECTIVES
The objective of the study was to determine whether postburn reduction of bone formation occurred earlier than 2-3 weeks after burn injury and whether that reduction was inversely related to marrow adiposity.
METHODS
Using a rat model of burn injury with sacrifice at 3 days postburn, we measured serum osteocalcin, a biomarker of bone formation, as well as a regulator of glucose metabolism, and counted tibial marrow adipocytes.
RESULTS
Serum osteocalcin was reduced as early as 3 days postburn, coinciding with a trend toward decline in marrow adipocyte number rather than demonstrating an inverse relationship with adipocyte count.
CONCLUSIONS
Factors that may be responsible for the dissociation include lack of circulating sclerostin, previously reported, increased energy demands following burn injury, increased sympathetic tone and perhaps oxidative stress. The relationship between bone formation and marrow adiposity is complex and subject to a variety of influences.

Keyword

Burns; Osteocalcin; Marrow adipocytes; Child; Bone formation

MeSH Terms

Adipocytes
Adiposity*
Animals
Bone Marrow*
Burns*
Child
Glucose
Humans
Metabolism
Models, Animal
Osteocalcin
Osteogenesis*
Oxidative Stress
Rats*
Glucose
Osteocalcin
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