J Korean Assoc Oral Maxillofac Surg.  2019 Oct;45(5):285-293. 10.5125/jkaoms.2019.45.5.285.

Reduction in post extraction waiting period for dental implant patients using plasma rich in growth factors: an in vivo study using cone-beam computed tomography

  • 1Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, SGT University, Gurgaon, India.
  • 2Department of Dentistry, Shaheed Hasan Khan Mewati (SHKM), Govt. Medical College, Nalhar, Nuh, Mewat, India. vijay_laxmy13@yahoo.co.in
  • 3Private Clinic, New Delhi, India.


This study examined the effects of plasma-rich growth factors (PRGF) on accelerating bone regeneration/repair in fresh extraction sockets, and determined the quality and quantity of bone by assessing the bone density using cone-beam computed tomography (CBCT).
Twenty patients, who had undergone bilateral extractions, were included in this study. In one extraction socket, PRGF was used and covered with an autologous fibrin plug. Nothing was used in the opposite side extraction socket. Thirteen weeks post extraction, the level of bone regeneration was evaluated on both sides with CBCT.
At the end of the study, the mean bone density according to the Hounsfield units (HU) in the control group and PRGF group was 500.05 HU (type III bone type) and 647.95 HU (type II bone type), respectively.
This study recommends the use of PRGF in post extraction sites to accelerate the rate of bone regeneration and improve the quality of regenerated bone. The technique to process PRGF was simple compared to previously mentioned techniques used for platelet-rich plasma (PRP) preparation. PRP preparation requires a two-cycle centrifugation procedure, leading to a longer processing time.


Plasma rich in growth factors; Bone regeneration/repair in fresh extraction sockets; Cone-beam computed tomography; Quality and quantity of bone; Platelet rich plasma

MeSH Terms

Bone Density
Bone Regeneration
Cone-Beam Computed Tomography*
Dental Implants*
Intercellular Signaling Peptides and Proteins*
Platelet-Rich Plasma
Dental Implants
Intercellular Signaling Peptides and Proteins


  • Fig. 1 Separated fractions. (PRGF: plasma-rich growth factors, RBCs: red blood cells, WBCs: white blood cells)

  • Fig. 2 A. Activated plasma-rich growth factors (PRGF). B. Gel like PRGF easily carried with forceps.

  • Fig. 3 A. Extraction socket. B. Extraction socket with plasma-rich growth factors.

  • Fig. 4 A. Preoperative cone-beam computed tomography (CBCT) image. B. Postoperative CBCT image.

  • Fig. 5 Patients bone density in Hounsfield units (HU). (PRGF: plasma-rich growth factors)

  • Fig. 6 Centrifugal machine for making plasma-rich growth factors.


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