J Periodontal Implant Sci.
2019 Oct;49(5):330-343. 10.5051/jpis.2019.49.5.330.
Comparative preclinical assessment of the use of dehydrated human amnion/chorion membrane to repair perforated sinus membranes
- Affiliations
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- 1Department of Dentistry, Inha International Medical Center, Incheon, Korea.
- 2Department of Periodontics, Asan Medical Center & Department of Dentistry, University of Ulsan College of Medicine, Seoul, Korea.
- 3Department of Periodontology, College of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea. grayheron@hanmail.net
- 4Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
- KMID: 2461023
- DOI: http://doi.org/10.5051/jpis.2019.49.5.330
Abstract
- PURPOSE
The aim of this study was to evaluate the use of dehydrated human amnion/chorion membrane (dHACM) to repair perforated sinus membranes in rabbits.
METHODS
Bilateral surgical windows (7.5-mm diameter) were prepared on the nasal bones of 14 rabbits. Standardized circular perforations (5-mm diameter) were made in the sinus membrane by manipulating implant twist drills. The perforated sinus membranes were repaired using dHACM or a resorbable collagen membrane (CM). The negative control (NC) group did not undergo perforated sinus membrane repair, while the positive control (PC) group underwent sinus augmentation without perforations. The same amount of deproteinized porcine bone mineral was grafted in all 4 groups. After 6 weeks, micro-computed tomography (micro-CT) and histomorphometric evaluations were conducted.
RESULTS
The micro-CT analysis revealed that the total augmented volume was not significantly different among the groups. In the dHACM group, newly formed bone filled the augmented area with remaining biomaterials; however, non-ciliated flat epithelium and inflammatory cells were observed on the healed sinus membrane. Histometric analysis showed that the percentage of newly formed bone area in the dHACM group did not differ significantly from that in the CM group. The dHACM group showed a significantly higher percentage of newly formed bone area than the NC group, but there was no significant difference between the dHACM and PC groups.
CONCLUSIONS
dHACM could be a feasible solution for repairing sinus membrane perforations that occur during sinus floor augmentation.
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