Diabetes Metab J.  2019 Feb;43(1):31-45. 10.4093/dmj.2019.0011.

Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • 2Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Korea.
  • 3Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. ejrhee.lee@samsung.com
  • 4Department of Internal Medicine, Wonkwang University Hospital, Wonkwang University School of Medicine, Iksan, Korea.

Abstract

Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This reciprocal relationship demonstrates the importance of confirming suspected NAFLD in patients with diabetes. Due to the invasive nature of liver biopsy to assess NAFLD status, various alternative non-invasive modalities have been developed and validated. Here, we summarized the epidemiology of NAFLD in patients with diabetes and reviewed currently available imaging modalities and biomarker-based prediction models for their ability to detect liver steatosis and/or fibrosis.

Keyword

Diabetes mellitus; Diagnosis; Epidemiology; Non-alcoholic fatty liver disease

MeSH Terms

Aging
Biopsy
Diabetes Complications
Diabetes Mellitus
Diabetes Mellitus, Type 2
Diagnosis*
Epidemiology*
Fatty Liver
Fibrosis
Humans
Liver
Non-alcoholic Fatty Liver Disease*
Prevalence
Risk Factors
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