Chonnam Med J.  2019 Sep;55(3):136-143. 10.4068/cmj.2019.55.3.136.

Reactive Oxygen Species Modulator 1 (ROMO1), a New Potential Target for Cancer Diagnosis and Treatment

• Amini MA
• Talebi SS
• Karimi J

• KMID: 2458565
• DOI: http://doi.org/10.4068/cmj.2019.55.3.136

Abstract

Today, the incidence of cancer in the world is rising, and it is expected that in the next several decades, the number of people suffering from cancer or (the cancer rate) will double. Cancer is defined as the excessive and uncontrolled growth of cells; of course (in simple terms), cancer is considered to be a set of other diseases that ultimately causes normal cells to be transformed into neoplastic cells. One of the most important causes of the onset and exacerbation of cancer is excessive oxidative stress. One of the most important proteins in the inner membrane of mitochondria is Reactive Oxygen Species (ROS) Modulator 1 (ROMO1) that interferes with the production of ROS, and with increasing the rate of this protein, oxidative stress will increase, which ultimately leads to some diseases, especially cancer. In this overview, we use some global databases to provide information about ROMO1 cellular signaling pathways, their related proteins and molecules, and some of the diseases associated with the mitochondrial protein, especially cancer.

Keyword

Reactive Oxygen Species; Neoplasms; Oxidative stress

MeSH Terms

Diagnosis*
Incidence
Membranes
Mitochondria
Mitochondrial Proteins
Oxidative Stress
Reactive Oxygen Species*
Mitochondrial Proteins
Reactive Oxygen Species

Figure

• 

  FIG. 1 This figure shows two important pathways that ROMO1 can play in the onset and progression of cancer. As we can see, it is possible to control this important protein using a Modulator, drug or everything and ultimately, with the signaling pathways, we can counteract with onset and progression of neoplasm.

• 

  FIG. 2 Scheme of how to put ROMO1 protein in mitochondria and its relationship with TIM21, complex V TIM23 complex (TIM23, TIM17A/B, TIM21, TIM50, and ROMO1 as well as TIM44 and HSP70) and MITRAC.

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