Clin Exp Reprod Med.
2019 Sep;46(3):125-131. 10.5653/cerm.2018.00416.
Differences in 25-hydroxy vitamin D and vitamin D-binding protein concentrations according to the severity of endometriosis
- Affiliations
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- 1Department of Obstetrics and Gynecology, Gyeongsang National University Changwon Hospital, Changwon, Korea.
- 2Department of Obstetrics and Gynecology, Gyeongsang National University Hospital, Jinju, Korea. choiwj@gnu.ac.kr
- 3Department of Obstetrics and Gynecology, Gyeongsang National University College of Medicine, Jinju, Korea.
- 4Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.
- 5Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea.
- KMID: 2458500
- DOI: http://doi.org/10.5653/cerm.2018.00416
Abstract
OBJECTIVE
To investigate serum 25-hydroxyl vitamin D (25(OH)D) and vitamin D-binding protein (VDBP) concentrations in women with endometriosis according to the severity of disease.
METHODS
Women with mild endometriosis (n = 9) and advanced endometriosis (n = 7), as well as healthy controls (n = 16), were enrolled in this observational study. Serum total 25(OH)D concentrations were analyzed using the Elecsys vitamin D total kit with the Cobas e602 module. Concentrations of bioavailable and free 25(OH)D were calculated. Concentrations of VDBP were measured using the Human Vitamin D BP Quantikine ELISA kit. Variables were tested for normality and homoscedasticity using the Shapiro-Wilk test and Leven F test, respectively. Correlation analysis was used to identify the variables related to total 25(OH)D and VDBP levels. To assess the effects of total 25(OH)D and VDBP levels in the three groups, multivariate generalized additive modeling (GAM) was performed.
RESULTS
Gravidity and parity were significantly different across the three groups. Erythrocyte sedimentation rate (ESR) and CA-125 levels increased as a function of endometriosis severity, respectively (p= 0.051, p= 0.004). The correlation analysis showed that total 25(OH)D levels were positively correlated with gravidity (r = 0.59, p< 0.001) and parity (r = 0.51, p< 0.003). Multivariate GAM showed no significant relationship of total 25(OH)D levels with EMT severity after adjusting for gravidity and ESR. However, the coefficient of total 25(OH)D levels with gravidity was significant (1.87; 95% confidence interval, 0.12-3.63; p= 0.040).
CONCLUSION
These results indicate that vitamin D and VDBP levels were not associated with the severity of endometriosis.
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